NCSTN
nicastrin
别名:
APH2
物种:
Human NCSTN (23385), Mouse Ncstn (59287), Rat Ncstn (289231), domestic cat NCSTN (101090586), sheep NCSTN (101120457), domestic guinea pig Ncstn (100731821), cow NCSTN (514929), chicken NCSTN (426905), naked mole-rat Ncstn (101718052), Zebrafish ncstn (494449) ...展开
UniProtKB ID:
基因ID:
- Human(23385) Summary: This gene encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Alternatively spliced transcript variants have been described, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
- Mouse(59287) nicastrin
- Rat(289231) nicastrin
- domestic cat(101090586) nicastrin
- sheep(101120457) nicastrin
- domestic guinea pig(100731821) nicastrin
- cow(514929) nicastrin
- chicken(426905) nicastrin
- naked mole-rat(101718052) nicastrin
- Zebrafish(494449) nicastrin
- dog(488638) nicastrin
- Horse(100058515) nicastrin
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Antibodies
货号
说明
物种反应性
应用
抗 呆蛋白 兔抗, IgG fraction of antiserum, buffered aqueous solution,
物种反应性
human, mouse, rat
应用
microarray
western blot
western blot
Anti-Nicastrin Antibody, ascites fluid, clone 9C3, Chemicon®,
物种反应性
human, mouse, rat
应用
immunocytochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-Nicastrin (ab1) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
物种反应性
human, mouse, rat
应用
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-Nicastrin (ab2) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
物种反应性
human, mouse, rat
应用
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-NCSTN antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunohistochemistry