HLA-DRB1
major histocompatibility complex, class II, DR beta 1
别名:
DRB1, DRw10, HLA-DR1B, HLA-DRB, SS1
物种:
UniProtKB ID:
基因ID:
- Human(3123) Summary: HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008]
- dog(474860) MHC class II DLA DRB1 beta chain
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Antibodies
货号
说明
物种反应性
应用
Anti-HLA-DRB1 Antibody, clone DJ9, clone DJ9, from mouse,
物种反应性
human
应用
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
Anti-HLA-DRB1 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
western blot
Anti-HLA-DRB1 antibody produced in rabbit, ,
物种反应性
human, mouse
应用
immunohistochemistry
western blot
western blot
Anti-HLA-DRB1 Antibody, clone 4D12 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
物种反应性
human
应用
affinity binding assay
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
Anti-HLA-DRB1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunohistochemistry
western blot
western blot