HAS2
hyaluronan synthase 2
别名:
物种:
Human HAS2 (3037), Mouse Has2 (15117), Rat Has2 (25694), Horse HAS2 (100009708), chicken HAS2 (395594), Zebrafish has2 (260350), cow HAS2 (281220), dog HAS2 (482032), Domestic Rabbit HAS2 (100008626), domestic cat HAS2 (101099432)
UniProtKB ID:
基因ID:
- Human(3037) Summary: Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1. [provided by RefSeq, Jul 2008]
- Mouse(15117) hyaluronan synthase 2
- Rat(25694) hyaluronan synthase 2
- Horse(100009708) hyaluronan synthase 2
- chicken(395594) hyaluronan synthase 2
- Zebrafish(260350) hyaluronan synthase 2
- cow(281220) hyaluronan synthase 2
- dog(482032) hyaluronan synthase 2
- Domestic Rabbit(100008626) hyaluronan synthase 2
- domestic cat(101099432) hyaluronan synthase 2
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Antibodies
货号
说明
物种反应性
应用
Anti-HAS2, clone 4E7 Antibody, clone 4E7, from mouse,
物种反应性
human
应用
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-Hyaluronan synthase 2 Antibody, clone 2B11.1, clone 2B11.1, from mouse,
物种反应性
human
应用
immunohistochemistry
western blot
western blot
ANTI-HAS2 (CENTER) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
物种反应性
human
应用
flow cytometry
immunohistochemistry
western blot
immunohistochemistry
western blot