CASP12
caspase 12 (gene/pseudogene)
别名:
CASP-12, CASP12P1
物种:
Human CASP12 (100506742), Mouse Casp12 (12364), Rat Casp12 (156117), dog CASP12 (479458), domestic cat CASP12 (100135767)
UniProtKB ID:
基因ID:
- Human(100506742) Summary: Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Feb 2011]
- Mouse(12364) caspase 12
- Rat(156117) caspase 12
- dog(479458) caspase 12
- domestic cat(100135767) caspase 12
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
货号
说明
物种反应性
应用
Anti-CASPASE-12 (ab1) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
物种反应性
human, mouse, rat
应用
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-Caspase-12 (small) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
物种反应性
human, mouse, rat
应用
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-Caspase-12 (large) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
物种反应性
human, mouse, rat
应用
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
抗-半胱天冬酶12单克隆抗体 大鼠抗, clone 14F7, purified immunoglobulin, buffered aqueous solution,
物种反应性
mouse, rat
应用
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
microarray
western blot
immunohistochemistry
immunoprecipitation (IP)
microarray
western blot
Anti-Caspase 12 Antibody, prodomain, aa 100-116, Chemicon®, from rabbit,
物种反应性
human, mouse, rat
应用
immunohistochemistry
western blot
western blot