跳转至内容

尊敬的客户:

目前国际形势复杂多变,关税政策尚不明朗,这可能对我们的产品价格产生一定影响。在此情况下,我们希望就订单事宜与您进行友好沟通。

基于当前的不确定性,如果您选择在此期间下单,我们将保留根据实际情况调整价格的权利。同时,我们也理解市场变化可能给您带来的困扰,因此如果在订单实际发货前因关税政策变动导致价格出现较大波动,默克将与您进行协商讨论并视情况对订单进行调整或取消。

关于应对近期政策变化的重要更新,请点击此处查看详情。

Merck
CN
  • Bcl-2, BAX, and apoptosis in endometrial hyperplasia after high dose gestagen therapy: a comparison of responses in patients treated with intrauterine levonorgestrel and systemic medroxyprogesterone.

Bcl-2, BAX, and apoptosis in endometrial hyperplasia after high dose gestagen therapy: a comparison of responses in patients treated with intrauterine levonorgestrel and systemic medroxyprogesterone.

Gynecologic oncology (2005-05-12)
Anne Beate Vereide, Turid Kaino, Georg Sager, Anne Ørbo
摘要

The aim of the study was to investigate apoptosis as a growth regulatory mechanism of gestagen in endometrial precancers and to compare differences in the apoptotic cascade after high and low dose gestagen regimens. Pre- and post-treatment paraffin-embedded endometrial hyperplasia specimens from women treated with levonorgestrel intrauterine device (n = 26) and women treated with 10 mg medroxyprogesterone for 10 days per cycle (n = 31) were examined for changes in the expression of Bcl-2 and BAX and the extent of apoptosis after 3 months of treatment. Immunohistochemical expression in tissue specimens for Bcl-2 and BAX was evaluated by H-score. Average number of apoptotic cells per hundred cells within ten different high power field (40 x) was evaluated for each section after in situ apoptosis detection (TUNEL method). A second group of patients with endometrial hyperplasia was examined after 1 week treatment with levonorgestrel IUD (n = 6) or medroxyprogesterone (n = 5) to determine early effects on expression of Bcl-2 and BAX and the extent of apoptosis. All the patients in the IUD group (n = 31) but only about half of the patients in per oral group (16 of 26) responded to treatment. The glandular reduction in Bcl-2 expression was markedly greater for the IUD patients than for the patients who received oral gestagen. The decrease in BAX expression after IUD treatment was less than the reduction of Bcl-2. Decrease in glandular Bcl-2 after 3 months of treatment was coincident with a significant increase in the measurable amount of apoptosis. In stromal cells, the increase in expression of Bcl-2 and BAX was found after gestagen treatment, the response being much more marked for the IUD group. The non- responders to per oral gestagen had no Bcl-2 expression in stroma after 3 months of therapy whereas an increase was observed for the responders. After 1 week, glandular Bcl-2 expression was significantly reduced after treatment in the IUD group. As for the rest, no changes were detected in either of the groups. Our results indicate that proteins in the apoptotic cascade are regulated by gestagen therapy in human endometrial precancers. Expression of these proteins is shown to be dependent on administration form and/or type of gestagen. Stromal Bcl-2 expression appears to be a potential biomarker which can separate responders of gestagen treatment from non-responders after oral administration.

材料
货号
品牌
产品描述

Supelco
ORBO 活性硅胶管, GFF,F,F separators, O.D. × L 7 mm × 100 mm, pkg of 50 ea
登录查看公司和协议定价
货号包装规格是否有货价格数量
25 μL
请联系客服了解存货情况
新价格,新优惠!
¥1,598.70
200 μL
请联系客服了解存货情况
¥4,826.02
0.5 mL
请联系客服了解存货情况
新价格,新优惠!
¥9,542.25
Supelco
ORBO Carboxen-564 管, W,F,F separators, O.D. × L 6 mm × 75 mm, pkg of 25 ea, for analyte group MEK (methylethyl ketone)
登录查看公司和协议定价
货号包装规格是否有货价格数量
25 μL
请联系客服了解存货情况
新价格,新优惠!
¥1,598.70
200 μL
请联系客服了解存货情况
¥4,826.02
0.5 mL
请联系客服了解存货情况
新价格,新优惠!
¥9,542.25
Supelco
ORBO 活性硅胶管, W,W,F separators, O.D. × L 6 mm × 75 mm, pkg of 50 ea
登录查看公司和协议定价
货号包装规格是否有货价格数量
25 μL
请联系客服了解存货情况
新价格,新优惠!
¥1,598.70
200 μL
请联系客服了解存货情况
¥4,826.02
0.5 mL
请联系客服了解存货情况
新价格,新优惠!
¥9,542.25
Supelco
ORBO 活性硅胶管, W,W,F separators, O.D. × L 6 mm × 75 mm, pkg of 50 ea
登录查看公司和协议定价
货号包装规格是否有货价格数量
25 μL
请联系客服了解存货情况
新价格,新优惠!
¥1,598.70
200 μL
请联系客服了解存货情况
¥4,826.02
0.5 mL
请联系客服了解存货情况
新价格,新优惠!
¥9,542.25
Supelco
ORBO 80 涂层过滤器, with cassettes: no, filter O.D. 37 mm, pkg of 25 ea
登录查看公司和协议定价
货号包装规格是否有货价格数量
25 μL
请联系客服了解存货情况
新价格,新优惠!
¥1,598.70
200 μL
请联系客服了解存货情况
¥4,826.02
0.5 mL
请联系客服了解存货情况
新价格,新优惠!
¥9,542.25
Supelco
ORBO Supelpak 20 系列管, W,W,W (specially treated) separators, O.D. × L 8 mm × 100 mm, pkg of 50 ea
登录查看公司和协议定价
货号包装规格是否有货价格数量
25 μL
请联系客服了解存货情况
新价格,新优惠!
¥1,598.70
200 μL
请联系客服了解存货情况
¥4,826.02
0.5 mL
请联系客服了解存货情况
新价格,新优惠!
¥9,542.25
Supelco
ORBO Carboxen-564 管, W,F,F separators, O.D. × L 6 mm × 75 mm, pkg of 25 ea, for analyte group Vinyl acetate
登录查看公司和协议定价
货号包装规格是否有货价格数量
25 μL
请联系客服了解存货情况
新价格,新优惠!
¥1,598.70
200 μL
请联系客服了解存货情况
¥4,826.02
0.5 mL
请联系客服了解存货情况
新价格,新优惠!
¥9,542.25
Supelco
ORBO Supelpak 20 系列管, RC,GFF,F,F (specially cleaned) separators, O.D. × L 13-8 mm × 75 mm , OSHA Versatile Sampler (OVS) Tube, pkg of 10 ea
登录查看公司和协议定价
货号包装规格是否有货价格数量
25 μL
请联系客服了解存货情况
新价格,新优惠!
¥1,598.70
200 μL
请联系客服了解存货情况
¥4,826.02
0.5 mL
请联系客服了解存货情况
新价格,新优惠!
¥9,542.25
Supelco
ORBO 402 Tenax® TA 经过特殊处理(35/60),100/50mg, W,W,W separators, O.D. × L 8 mm × 100 mm, pkg of 50 ea
登录查看公司和协议定价
货号包装规格是否有货价格数量
25 μL
请联系客服了解存货情况
新价格,新优惠!
¥1,598.70
200 μL
请联系客服了解存货情况
¥4,826.02
0.5 mL
请联系客服了解存货情况
新价格,新优惠!
¥9,542.25
Supelco
ORBO Amberlite XAD-2 管, W,W,W separators, O.D. × L 8 mm × 110 mm, pkg of 50 ea
登录查看公司和协议定价
货号包装规格是否有货价格数量
25 μL
请联系客服了解存货情况
新价格,新优惠!
¥1,598.70
200 μL
请联系客服了解存货情况
¥4,826.02
0.5 mL
请联系客服了解存货情况
新价格,新优惠!
¥9,542.25
Supelco
ORBO 活性硅胶管, W,W,W separators, O.D. × L 6 mm × 75 mm, pkg of 50 ea
登录查看公司和协议定价
货号包装规格是否有货价格数量
25 μL
请联系客服了解存货情况
新价格,新优惠!
¥1,598.70
200 μL
请联系客服了解存货情况
¥4,826.02
0.5 mL
请联系客服了解存货情况
新价格,新优惠!
¥9,542.25
Supelco
ORBO Amberlite XAD-4 管, RC,GFF,F,F (specially cleaned) separators, O.D. × L 13-8 mm × 75 mm , OSHA Versatile Sampler (OVS), pkg of 10 ea
登录查看公司和协议定价
货号包装规格是否有货价格数量
25 μL
请联系客服了解存货情况
新价格,新优惠!
¥1,598.70
200 μL
请联系客服了解存货情况
¥4,826.02
0.5 mL
请联系客服了解存货情况
新价格,新优惠!
¥9,542.25
Supelco
ORBO 80 涂层过滤器, with cassettes unassembled
登录查看公司和协议定价
货号包装规格是否有货价格数量
25 μL
请联系客服了解存货情况
新价格,新优惠!
¥1,598.70
200 μL
请联系客服了解存货情况
¥4,826.02
0.5 mL
请联系客服了解存货情况
新价格,新优惠!
¥9,542.25
Supelco
Supelpak 20N 管上的 ORBO 2-HMP, W,W,W separators, O.D. × L 6 mm × 85 mm, pkg of 25 ea
登录查看公司和协议定价
货号包装规格是否有货价格数量
25 μL
请联系客服了解存货情况
新价格,新优惠!
¥1,598.70
200 μL
请联系客服了解存货情况
¥4,826.02
0.5 mL
请联系客服了解存货情况
新价格,新优惠!
¥9,542.25
Supelco
Supelpak 20N 管上的 ORBO 2-HMP, W,W,W separators, O.D. × L 6 mm × 105 mm, pkg of 25 ea
登录查看公司和协议定价
货号包装规格是否有货价格数量
25 μL
请联系客服了解存货情况
新价格,新优惠!
¥1,598.70
200 μL
请联系客服了解存货情况
¥4,826.02
0.5 mL
请联系客服了解存货情况
新价格,新优惠!
¥9,542.25