Musashi-1 promotes a cancer stem cell lineage and chemoresistance in colorectal cancer cells.

Musashi-1 promotes a cancer stem cell lineage and chemoresistance in colorectal cancer cells.

Scientific reports (2017-05-21)

Guang-Yuh Chiou, Tzu-Wei Yang, Chi-Chou Huang, Chia-Ying Tang, Jung-Yi Yen, Ming-Chang Tsai, Hsuan-Yi Chen, Nurul Fadhilah, Chun-Che Lin, Yuh-Jyh Jong

PMID28526879

摘要

Colorectal cancers (CRCs) are a critical health issue worldwide. Cancer stem cell (CSC) lineages are associated with tumour transformation, progression, and malignant transformation. However, how lineages are transformed and how chemoresistance is acquired by CRCs remain largely unknown. In this report, we demonstrated that the RNA-binding protein Musashi-1 enhanced the development of CD44

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产品描述

F3165

Sigma-Aldrich

单克隆抗-FLAG^® M2 小鼠抗, clone M2, purified immunoglobulin (Purified IgG1 subclass), buffered aqueous solution (10 mM sodium phosphate, 150 mM NaCl, pH 7.4, containing 0.02% sodium azide)

X100

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Triton^™ X-100, laboratory grade

F7425

Millipore

抗-FLAG^® 兔抗, affinity isolated antibody, buffered aqueous solution

SAB4700182

Sigma-Aldrich

Monoclonal Anti-CD44-FITC antibody produced in mouse, clone MEM-85, purified immunoglobulin, buffered aqueous solution