SMAD3 Regulates Follicle-stimulating Hormone Synthesis by Pituitary Gonadotrope Cells

SMAD3 Regulates Follicle-stimulating Hormone Synthesis by Pituitary Gonadotrope Cells

The Journal of biological chemistry (2016-12-21)

Yining Li, Gauthier Schang, Ulrich Boehm, Chu-Xia Deng, Jonathan Graff, Daniel J Bernard

摘要

Pituitary follicle-stimulating hormone (FSH) is an essential regulator of fertility in females and of quantitatively normal spermatogenesis in males. Pituitary-derived activins are thought to act as major stimulators of FSH synthesis by gonadotrope cells.

材料

货号

品牌

产品描述

T48402

Sigma-Aldrich

2,2,2-三溴乙醇, 97%

H3884

Sigma-Aldrich

透明质酸酶来源于牛睾丸, Type IV-S, lyophilized powder (essentially salt-free), 750-3000 units/mg solid

P6148

Sigma-Aldrich

多聚甲醛, reagent grade, crystalline

M7653

Sigma-Aldrich

培养基 199, With Hanks′ salts and sodium bicarbonate, without L-glutamine, liquid, sterile-filtered, suitable for cell culture