跳转至内容

CN

Functional understanding of the versatile protein copper metabolism MURR1 domain 1 (COMMD1) in copper homeostasis.

Functional understanding of the versatile protein copper metabolism MURR1 domain 1 (COMMD1) in copper homeostasis.

Annals of the New York Academy of Sciences (2014-04-05)

Alina Fedoseienko, Paulina Bartuzi, Bart van de Sluis

摘要

Copper is an important cofactor in numerous biological processes in all living organisms. However, excessive copper can be extremely toxic, so it is vital that the copper level within a cell is tightly regulated. The damaging effect of copper is seen in several hereditary forms of copper toxicity in humans and animals. At present, Wilson's disease is the best-described and best-studied copper-storage disorder in humans; it is caused by mutations in the ATP7B gene. In dogs, a mutation in the COMMD1 gene has been found to be associated with copper toxicosis. Using a liver-specific Commd1 knockout mouse, the biological role of Commd1 in copper homeostasis has been confirmed. Yet, the exact mechanism by which COMMD1 regulates copper homeostasis is still unknown. Here, we give an overview of the current knowledge and perspectives on the molecular function of COMMD1 in copper homeostasis.

材料

货号

品牌

产品描述

Sigma-Aldrich

铜, powder, 99.999% trace metals basis

Sigma-Aldrich

铜, foil, thickness 0.25 mm, 99.98% trace metals basis

Sigma-Aldrich

铜, powder, <425 μm, 99.5% trace metals basis

Sigma-Aldrich

铜, wire, diam. 1.0 mm, ≥99.9%

Sigma-Aldrich

铜, nanopowder, 40-60 nm particle size (SAXS), ≥99.5% trace metals basis

Sigma-Aldrich

铜, powder (dendritic), <45 μm, 99.7% trace metals basis

Sigma-Aldrich

铜, powder (spheroidal), 10-25 μm, 98%

Sigma-Aldrich

铜, nanopowder, 60-80 nm particle size (SAXS), ≥99.5% trace metals basis

Sigma-Aldrich

铜, wire, diam. 0.25 mm, 99.999% trace metals basis

Sigma-Aldrich

铜, powder, <75 μm, 99%

Sigma-Aldrich

铜, foil, thickness 0.025 mm, 99.98% trace metals basis

Sigma-Aldrich

铜, foil, ≥99.8% (complexometric)

Sigma-Aldrich

铜, turnings, purum p.a., ≥99.0%

Sigma-Aldrich

铜, foil, thickness 0.5 mm, 99.98% trace metals basis

Sigma-Aldrich

铜, ACS reagent, granular, 10-40 mesh, ≥99.90%

Sigma-Aldrich

铜, beads, 2-8 mm, 99.9995% trace metals basis

Sigma-Aldrich

铜, foil, thickness 1.0 mm, 99.999% trace metals basis

Sigma-Aldrich

铜, shot, −3-+14 mesh, 99%

Sigma-Aldrich

铜, wire, diam. 0.64 mm, 99.995% trace metals basis

铜, rod, 50mm, diameter 6.35mm, as drawn, 99.999%

Sigma-Aldrich

铜, wire, diam. 2.0 mm, 99.999% trace metals basis

Sigma-Aldrich

铜, beads, 2-8 mm, ≥99.99% trace metals basis

铜, mesh, 100x100mm, nominal aperture 0.14mm, thickness 0.25mm, wire diameter 0.115mm, 100x100 wires/inch, open area 30.3%, plain weave mesh

铜, sheet, 150x150mm, thickness 3.0mm, 99.95+%

铜, insulated wire, 50m, conductor diameter 0.05mm, insulation thickness 0.002mm, 2 micron polyesterimide insulation, 99.9%

铜, tube, 100mm, outside diameter 3.5mm, inside diameter 1.56mm, wall thickness 0.97mm, as drawn, 99.9%

铜, rod, 1000mm, diameter 4.8mm, hard, 99.9%

铜, foil, 100x100mm, thickness 0.1mm, hard, 99.95+%

铜, foil, 25mm disks, thickness 0.25mm, annealed, 99.95+%

铜, wire reel, 10m, diameter 0.025mm, as drawn, 99.99+%