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Merck
CN
  • New DNA minor-groove binding molecules with high sequence-selectivities and binding affinities.

New DNA minor-groove binding molecules with high sequence-selectivities and binding affinities.

Biochemical and biophysical research communications (1997-12-17)
B Gong, Y Yan
摘要

New DNA minor-groove binding molecules with high binding affinities and sequence-selectivities are described. The effects of structural changes in ligands with a three-ring backbone on their DNA-binding properties have been studied. Of a pool of eight potential ligands, two showed binding affinities and sequence-selectivities rivaling distamycin. The two best ligands share a common structural motif that involves a para-di-substituted benzene ring flanked by two meta-di-substituted benzene rings.

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Sigma-Aldrich
聚脱氧腺苷酸•聚胸苷酸 钠盐, double-stranded homopolymer