- Diastereoselective synthesis of substituted dihydropyrans via an oxonium-ene cyclization reaction.
Diastereoselective synthesis of substituted dihydropyrans via an oxonium-ene cyclization reaction.
Organic & biomolecular chemistry (2012-10-06)
Pipas Saha, Priya Ghosh, Sabera Sultana, Anil K Saikia
PMID23037969
摘要
Substituted dihydropyrans can be efficiently synthesized in good yields with excellent diastereoselectivity from the reaction of aldehydes or epoxides and ethyl 3-alkyl-3-hydroxy-5-methylhex-5-enoate via an oxonium-ene cyclization reaction catalyzed by trimethylsilyl trifluoromethanesulfonate (TMSOTf) under mild conditions.