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Merck
CN
  • Design and characterization of bi-soft segmented polyurethane microparticles for biomedical application.

Design and characterization of bi-soft segmented polyurethane microparticles for biomedical application.

Colloids and surfaces. B, Biointerfaces (2011-08-09)
Elisa Campos, Rosemeyre Cordeiro, Ana Cristina Santos, Cláudia Matos, M H Gil
摘要

Bi-soft segmented poly(ester urethane urea) microparticles were prepared and characterized aiming a biomedical application. Two different formulations were developed, using poly(propylene glycol), tolylene 2,4-diisocyanate terminated pre-polymer (TDI) and poly(propylene oxide)-based tri-isocyanated terminated pre-polymer (TI). A second soft segment was included due to poly(ɛ-caprolactone) diol (PCL). Infrared spectroscopy, used to study the polymeric structure, namely its H-bonding properties, revealed a slightly higher degree of phase separation in TDI-microparticles. TI-microparticles presented slower rate of hydrolytic degradation, and, accordingly, fairly low toxic effect against macrophages. These new formulations are good candidates as non-biodegradable biomedical systems.

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聚丙二醇, P 2,000
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聚丙二醇, P 400
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聚(丙二醇), average Mn ~425
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聚(丙二醇), average Mn ~1,000
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聚(丙二醇), average Mn ~2,000
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聚(丙二醇), average Mn ~4,000
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Sigma-Aldrich
聚(丙二醇), average Mn ~725
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Sigma-Aldrich
聚(丙二醇), average Mn ~2,700
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