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Does HAART dysregulate angiogenesis in HIV infected preeclampsia?

Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria (2022-08-11)
Sayuri Padayachee, Nalini Govender, Thajasvarie Naicker
摘要

A dysregulation of angiogenic mediators has been implicated in HIV infection. Inconsistent data exists on highly active antiretroviral therapy (HAART) usage in pregnancy and its association with PE development. In view of the high prevalence of HIV infection and PE in SA, this study was aimed at determining PlGF and sFlt-1 levels in HIV-infected normotensive and preeclamptic pregnancies treated with HAART. Both PlGF and sFlt-1 were quantified in serum from HIV positive [normotensive (N+) and preeclamptic (P+)]; and HIV negative [normotensive (N-) and preeclamptic (P-)] pregnancies, using a Milliplex Multiplex immunoassay. sFlt-1 was significantly upregulated in P+ vs the N+ groups. PlGF was significantly downregulated in PE vs normotensive groups, regardless of HIV status. sFlt-1/PlGF ratio was significantly increased in PE- vs the N- groups. We report an amplification of sFlt-1 in lieu of PlGF down-regulation in HIV-infected pregnancies receiving HAART .

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Millipore
MILLIPLEX® 人血管生成/生长因子磁珠板 - 癌症多重检测, Angiogenesie Bead-Based Multiplex Assays using the Luminex technology enables the simultaneous analysis of multiple angiogenic biomarkers in human serum, plasma and cell culture samples.
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Millipore
MILLIPLEX® 人血管生成板2,HANG2MAG-12K, Angiogenesis Bead-Based Multiplex Assays using the Luminex technology enables the simultaneous analysis of multiple angiogenic biomarkers in human serum, plasma and cell culture samples.
登录查看公司和协议定价
货号包装规格是否有货价格数量
1 mL
国内现货,预计发货时间 2025年4月15日
详情...
¥736.34
5 mL
国内现货,预计发货时间 2025年4月15日
详情...
¥2,918.48
10 x 1 mL
请联系客服了解存货情况
¥7,883.24