跳转至内容

Dear Customer:

The current international situation is complex and volatile, and uncertain tariff policies may potentially impact our product prices. Given these uncertainties, we value your understanding regarding order-related matters.

If you decide to place an order during this period, we reserve the right to adjust the price based on the evolving situation. We understand that market changes may cause inconvenience. We will negotiate with you if there’s a significant price fluctuation due to tariff policy changes before the order’s actual delivery, and in such cases we may adjust or cancel the order as necessary.

Merck
CN
  • Fruquintinib inhibits VEGF/VEGFR2 axis of choroidal endothelial cells and M1-type macrophages to protect against mouse laser-induced choroidal neovascularization.

Fruquintinib inhibits VEGF/VEGFR2 axis of choroidal endothelial cells and M1-type macrophages to protect against mouse laser-induced choroidal neovascularization.

Cell death & disease (2020-11-29)
Xiaojuan Liu, Aisong Guo, Yuanyuan Tu, Wendie Li, Lele Li, Wangrui Liu, Yuanyuan Ju, Yamei Zhou, Aimin Sang, Manhui Zhu
摘要

Wet age-related macular degeneration, which is characterized by choroidal neovascularization (CNV) and induces obvious vision loss. Vascular endothelial growth factor (VEGF) family member VEGF-A (also named as VEGF) and its receptor VEGFR2 contribute to the pathogenesis of CNV. Choroidal endothelial cells (CECs) secret C-C motif chemokine ligand 2 (CCL2), which attracts macrophages to CNV lesion and promotes macrophage M1 polarization. Accordingly, infiltrating macrophages secret inflammatory cytokines to promote CNV. In vivo, intravitreal injection of fruquintinib (HMPL-013), an antitumor neovascularization drug, alleviated mouse CNV formation without obvious ocular toxicity. Meanwhile, HMPL-013 inhibited VEGF/VEGFR2 binding in CECs and macrophages, as well as macrophage M1 polarization. In vitro, noncontact coculture of human choroidal vascular endothelial cells (HCVECs) and macrophages under hypoxia conditions was established. HMPL-013 downregulated VEGF/VEGFR2/phosphoinositide-3-kinase/protein kinase B (AKT)/nuclear factor kappa B pathway and CCL2 secretion in HCVECs, as well as VEGF/VEGFR2-induced macrophage M1 polarization under hypoxia condition. In addition, HMPL-013 inhibited HCEVC derived CCL2-induced macrophage migration and M1 polarization, along with macrophage M1 polarization-induced HCVECs proliferation, migration, and tube formation. Altogether, HMPL-013 alleviated CNV formation might via breaking detrimental cross talk between CECs and macrophages.

材料
货号
品牌
产品描述

Roche
原位细胞死亡检测试剂盒,荧光素法, sufficient for ≤50 tests, suitable for detection
登录查看公司和协议定价
货号包装规格是否有货价格数量
1 mL
国内现货,预计发货时间 April 15, 2025
详情...
CN¥736.34
5 mL
国内现货,预计发货时间 April 15, 2025
详情...
CN¥2,918.48
10 x 1 mL
请联系客服了解存货情况
CN¥7,883.24
Sigma-Aldrich
脂多糖 来源于大肠杆菌 0127:B8, purified by phenol extraction
登录查看公司和协议定价
货号包装规格是否有货价格数量
1 mL
国内现货,预计发货时间 April 15, 2025
详情...
CN¥736.34
5 mL
国内现货,预计发货时间 April 15, 2025
详情...
CN¥2,918.48
10 x 1 mL
请联系客服了解存货情况
CN¥7,883.24
Sigma-Aldrich
来自西非单叶豆加纳籽)的凝集素, Isolectin B4 (BSI-B4), FITC conjugate, lyophilized powder
登录查看公司和协议定价
货号包装规格是否有货价格数量
1 mL
国内现货,预计发货时间 April 15, 2025
详情...
CN¥736.34
5 mL
国内现货,预计发货时间 April 15, 2025
详情...
CN¥2,918.48
10 x 1 mL
请联系客服了解存货情况
CN¥7,883.24
Sigma-Aldrich
小鼠 IL-6 ELISA 试剂盒, for cell and tissue lysates
登录查看公司和协议定价
货号包装规格是否有货价格数量
1 mL
国内现货,预计发货时间 April 15, 2025
详情...
CN¥736.34
5 mL
国内现货,预计发货时间 April 15, 2025
详情...
CN¥2,918.48
10 x 1 mL
请联系客服了解存货情况
CN¥7,883.24
Sigma-Aldrich
小鼠 MCP-1/CCL2 ELISA 试剂盒, for serum, plasma and cell culture supernatant
登录查看公司和协议定价
货号包装规格是否有货价格数量
1 mL
国内现货,预计发货时间 April 15, 2025
详情...
CN¥736.34
5 mL
国内现货,预计发货时间 April 15, 2025
详情...
CN¥2,918.48
10 x 1 mL
请联系客服了解存货情况
CN¥7,883.24
Millipore
ProteoPrep® 总蛋白提取试剂盒
登录查看公司和协议定价
货号包装规格是否有货价格数量
1 mL
国内现货,预计发货时间 April 15, 2025
详情...
CN¥736.34
5 mL
国内现货,预计发货时间 April 15, 2025
详情...
CN¥2,918.48
10 x 1 mL
请联系客服了解存货情况
CN¥7,883.24
Sigma-Aldrich
小鼠RANTES / CCL5 ELISA试剂盒, for serum, plasma and cell culture supernatant
登录查看公司和协议定价
货号包装规格是否有货价格数量
1 mL
国内现货,预计发货时间 April 15, 2025
详情...
CN¥736.34
5 mL
国内现货,预计发货时间 April 15, 2025
详情...
CN¥2,918.48
10 x 1 mL
请联系客服了解存货情况
CN¥7,883.24