跳转至内容

尊敬的客户:

目前国际形势复杂多变,关税政策尚不明朗,这可能对我们的产品价格产生一定影响。在此情况下,我们希望就订单事宜与您进行友好沟通。

基于当前的不确定性,如果您选择在此期间下单,我们将保留根据实际情况调整价格的权利。同时,我们也理解市场变化可能给您带来的困扰,因此如果在订单实际发货前因关税政策变动导致价格出现较大波动,默克将与您进行协商讨论并视情况对订单进行调整或取消。

关于应对近期政策变化的重要更新,请点击此处查看详情。

Merck
CN
  • Repurposing the psoriasis drug Oxarol to an ointment adjuvant for the influenza vaccine.

Repurposing the psoriasis drug Oxarol to an ointment adjuvant for the influenza vaccine.

International immunology (2020-02-16)
Ryota Sato, Chieko Makino-Okamura, Quingshun Lin, Muying Wang, Jason E Shoemaker, Tomohiro Kurosaki, Hidehiro Fukuyama
摘要

Aluminum precipitates have long been used as adjuvants for human vaccines, but there is a clear need for safer and more effective adjuvants. Here we report in a mouse model that the psoriasis drug Oxarol ointment is a highly effective vaccine adjuvant. By applying Oxarol ointment onto skin, humoral responses and germinal center (GC) reactions were augmented, and the treated mice were protected from death caused by influenza virus infection. Keratinocyte-specific vitamin D3 receptor (Vdr) gene expression was required for these responses through induction of the thymic stromal lymphopoietin (Tslp) gene. Experiments involving administration of recombinant TSLP or, conversely, anti-TSLP antibody demonstrated that TSLP plays a key role in the GC reactions. Furthermore, cell-type-specific Tslpr gene deletion or diphtheria toxin-mediated deletion of specific cell types revealed that CD11c+ cells excluding Langerhans cells were responsible for the Oxarol-mediated GC reactions. These results indicate that active vitamin D3 is able to enhance the humoral response via Tslp induction in the skin and serves as a new vaccine adjuvant.

材料
货号
品牌
产品描述

Sigma-Aldrich
4-羟基-3-硝基苯乙酸, 99%
登录查看公司和协议定价
货号包装规格是否有货价格数量
100 μL
国内现货,预计发货时间 2025年4月21日
详情...
¥5,169.41
0.2 mL
国内现货,预计发货时间 2025年4月21日
详情...
¥9,425.34
0.5 mL
国内现货,预计发货时间 2025年4月21日
详情...
¥17,956.83