Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels.

Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels.

Bioorganic & medicinal chemistry letters (2005-12-29)

Kathleen H Mortell, David J Anderson, James J Lynch, Sherry L Nelson, Kathy Sarris, Heath McDonald, Reza Sabet, Scott Baker, Prisca Honore, Chih-Hung Lee, Michael F Jarvis, Murali Gopalakrishnan

PMID16380257

摘要

A series of alpha-amino acids were identified as ligands which compete with gabapentin for binding to the alpha(2)delta subunit of voltage-dependent Ca(2+) channels. Potent analogs were identified. Their activity in an in vivo pain assay is described.

材料

货号

品牌

产品描述

P5482

Sigma-Aldrich

L-苯基丙氨酸, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 98.5-101.0%

78019

Sigma-Aldrich

L-苯基丙氨酸, BioUltra, ≥99.0% (NT)

P25485

Sigma-Aldrich