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Merck
CN
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文件

G154

Sigma-Aldrich

加巴喷丁

solid

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别名:
1-（氨甲基）-环己烷乙酸, 加巴喷丁
经验公式（希尔记法）:
C9H17NO2
CAS号:
60142-96-3
分子量:
171.24
Beilstein:
2359739
EC 号:
262-076-3
MDL编号:
MFCD00865286
UNSPSC代码:
12352200
PubChem化学物质编号:
24278159
NACRES:
NA.77

形式

solid

质量水平

200

颜色

off-white

溶解性

H2O: 10 mg/mL

SMILES字符串

NCC1(CC(O)=O)CCCCC1

InChI

1S/C9H17NO2/c10-7-9(6-8(11)12)4-2-1-3-5-9/h1-7,10H2,(H,11,12)

InChI key

UGJMXCAKCUNAIE-UHFFFAOYSA-N

基因信息

human ... ADORA1(134) , CACNA1A(773) , CACNA1B(774) , CACNA1C(775) , CACNA1D(776) , CACNA1E(777) , CACNA1F(778) , CACNA1G(8913) , CACNA1H(8912) , CACNA1I(8911) , CACNA1S(779) , CACNA2D1(781) , CACNA2D2(9254) , CACNA2D3(55799) , CACNA2D4(93589) , CACNB1(782) , CACNB2(783) , CACNB3(784) , CACNB4(785) , CACNG1(786) , CACNG2(10369) , CACNG3(10368) , CACNG4(27092) , CACNG5(27091) , CACNG6(59285) , CACNG7(59284) , CACNG8(59283)
rat ... Cacna1a(25398)

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应用

加巴喷丁已被用于：
  • 作为 α2δ-配体，以检查异硫氰酸烯丙酯 (AITC) 敏化热厌恶试验是否可作为鉴别假定镇痛药的筛选方法
  • 溶于摄取缓冲液，使用液相色谱-质谱法通过有机阳离子转运蛋白 2 (OCTN2) 测定 ASP（反式-4-[4-（二甲氨基）苯乙烯基]-1-甲基吡啶碘）底物
  • 用作腹腔内注射的镇痛佐剂

生化/生理作用

作用机制不明的抗惊厥药；可通过血脑屏障；增加脑内 GABA 浓度，减少兴奋性氨基酸神经传递，可能是通过其对电压门控钙通道的作用；表现出抗伤害、抗焦虑、神经保护和抗癫痫作用。
加巴喷丁作为 L 型钙通道 α2δ 亚单位的配体。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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