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Merck
CN

Patient derived organoids to model rare prostate cancer phenotypes.

Nature communications (2018-06-21)
Loredana Puca, Rohan Bareja, Davide Prandi, Reid Shaw, Matteo Benelli, Wouter R Karthaus, Judy Hess, Michael Sigouros, Adam Donoghue, Myriam Kossai, Dong Gao, Joanna Cyrta, Verena Sailer, Aram Vosoughi, Chantal Pauli, Yelena Churakova, Cynthia Cheung, Lesa Dayal Deonarine, Terra J McNary, Rachele Rosati, Scott T Tagawa, David M Nanus, Juan Miguel Mosquera, Charles L Sawyers, Yu Chen, Giorgio Inghirami, Rema A Rao, Carla Grandori, Olivier Elemento, Andrea Sboner, Francesca Demichelis, Mark A Rubin, Himisha Beltran
摘要

A major hurdle in the study of rare tumors is a lack of existing preclinical models. Neuroendocrine prostate cancer is an uncommon and aggressive histologic variant of prostate cancer that may arise de novo or as a mechanism of treatment resistance in patients with pre-existing castration-resistant prostate cancer. There are few available models to study neuroendocrine prostate cancer. Here, we report the generation and characterization of tumor organoids derived from needle biopsies of metastatic lesions from four patients. We demonstrate genomic, transcriptomic, and epigenomic concordance between organoids and their corresponding patient tumors. We utilize these organoids to understand the biologic role of the epigenetic modifier EZH2 in driving molecular programs associated with neuroendocrine prostate cancer progression. High-throughput organoid drug screening nominated single agents and drug combinations suggesting repurposing opportunities. This proof of principle study represents a strategy for the study of rare cancer phenotypes.

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Sigma-Aldrich
抗肌动蛋白抗体,克隆C4, ascites fluid, clone C4, Chemicon®
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CN¥1,758.71
25 g
国内现货,预计发货时间 April 08, 2025
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Sigma-Aldrich
GSK343, ≥98% (HPLC)
登录查看公司和协议定价
货号包装规格是否有货价格数量
5 g
国内现货,预计发货时间 April 08, 2025
详情...
CN¥1,758.71
25 g
国内现货,预计发货时间 April 08, 2025
详情...
CN¥6,630.66