所有图片(3)
About This Item
经验公式（希尔记法）:
C8H15N3O7
CAS号:
分子量:
265.22
Beilstein:
2060675
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
等级
reagent grade
产品线
Vetec™
检测方案
98%
形式
powder
mp
121 °C (dec.) (lit.)
储存温度
−20°C
SMILES字符串
CN(N=O)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O
InChI
1S/C8H15N3O7/c1-11(10-17)8(16)9-4-6(14)5(13)3(2-12)18-7(4)15/h3-7,12-15H,2H2,1H3,(H,9,16)/t3-,4-,5-,6-,7+/m1/s1
InChI key
ZSJLQEPLLKMAKR-GKHCUFPYSA-N
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一般描述
链脲菌素（STZ 或 2-脱氧-2（3-甲基-3-亚硝基脲基）-d-吡喃葡萄糖）是一种抗生素，主要从无色链霉菌中分离得到。
应用
链脲菌素已用于：
- 小鼠腹腔注射，用于做动物实验
- 在柠檬酸钠缓冲液中腹腔注射小鼠，进行体内 STZ 处理，用于对胰腺内分泌细胞进行单细胞 RNA 测序
- 诱导小鼠糖尿病/糖尿病视网膜病变（DR）研究小胶质细胞脾脏酪氨酸激酶（Syk）在 DR 中的作用
生化/生理作用
一种在胰岛中可作为一氧化氮供体的含N-亚硝基化合物；诱导胰岛素分泌细胞的死亡，产生糖尿病动物模型。可诱导染色体断裂的有效DNA甲基化剂。 对表达GLUT2葡萄糖转运蛋白的神经内分泌肿瘤细胞系具有细胞毒性。
链脲菌素（STZ 或 2-脱氧-2（3-甲基-3-亚硝基脲基）-d-吡喃葡萄糖）是一种能导致胰腺 β-细胞破坏的强效烷基化剂，被用作诱导胰岛素依赖型糖尿病（IDDM）的实验药物。它具有溶瘤、抗肿瘤、致癌和致糖尿病的特性。这种抗肿瘤药物用于治疗转移性胰岛细胞癌。STZ 可以直接使 DNA 甲基化，并且具有高度的遗传毒性。
法律信息
Vetec is a trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Warning
危险声明
危险分类
Carc. 2 - Flam. Sol. 2 - Muta. 2
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
涉药品监管产品
Mouse models of insulin dependent diabetes: low-dose streptozocin-induced diabetes and nonobese diabetic (NOD) mice.
H Kolb
Diabetes/metabolism reviews, 3(3), 751-778 (1987-07-01)
Eri Mukai et al.
Diabetes research and clinical practice, 106(2), 303-311 (2014-09-30)
Spontaneously diabetic Torii (SDT) rats exhibit vascular abnormalities in pancreatic islets as the initial changes at pre-diabetes stage (8 weeks old), which is followed by β cell deterioration. In the present study, we investigated pathophysiological interactions between β cells and
Johnathan K Smid et al.
Endocrinology, 156(3), 824-836 (2014-12-09)
We found that the secreted protein periostin (Postn) is highly induced after partial pancreatectomy in regenerating areas containing mesenchymal stroma and tubular complexes. Importantly, after partial pancreatectomy, Postn-deficient mice exhibit impaired mesenchymal formation and reduced regeneration specifically within the pancreatic
Streptozocin: a review of its pharmacology, efficacy, and toxicity.
R B Weiss
Cancer treatment reports, 66(3), 427-438 (1982-03-01)
Greg Tesch et al.
Diabetologia, 57(9), 1977-1985 (2014-06-25)
The AGEs and the receptor for AGEs (RAGE) are known contributors to diabetic complications. RAGE also has a physiological role in innate and adaptive immunity and is expressed on immune cells. The aim of this study was to determine whether
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