推荐产品
等级
reagent grade
产品线
Vetec™
方案
≥97%
表单
powder
技术
HPLC: suitable
颜色
yellow to orange
mp
>285 °C
SMILES字符串
NC(N1)=NC(C2=C1N=CC(CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)=O
InChI
1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1
InChI key
OVBPIULPVIDEAO-LBPRGKRZSA-N
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一般描述
叶酸属于维生素B族的一员，也称为维生素9。它在人体中以5-甲基四氢叶酸形式存在。叶酸的膳食来源为谷物、水果和蔬菜。蝶酰谷氨酸是一种合成叶酸，含有一个谷氨酸并以氧化形式存在。
生化/生理作用
叶酸是细胞生长、大脑功能的必需组分，并在甘氨酸生产丝氨酸中发挥重要作用。它还可协同维生素B12维持铁浓度水平。叶酸缺乏会引起巨红细胞性贫血症。叶酸有助于DNA的修复与合成。对于孕妇，特别是怀孕早期孕妇，建议在膳食中增补叶酸，防止先天性畸形和神经管缺陷 (NTD)。但叶酸增补也可能会增加前列腺癌风险。在结肠癌细胞中添加叶酸会降低铁浓度并对细胞分裂造成损伤。
法律信息
Vetec is a trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 1
Folic acid supplementation for pregnant women and those planning pregnancy: 2015 update
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Journal of Clinical Pharmacology, 56(2), 170-175 (2016)
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BMJ Open, 2(1), e000653-e000653 (2012)
High folic acid increases cell turnover and lowers differentiation and iron content in human HT29 colon cancer cells
Pellis L, et al.
The British Journal of Nutrition, 99(4), 703-708 (2008)
The metabolic processes of folic acid and Vitamin B12 deficiency
Mahmood L
Journal of Health Research and Reviews, 1(1), 5-5 (2014)
Tor A Strand et al.
Pediatrics, 135(4), e918-e926 (2015-03-25)
Folate and vitamin B-12 are important for growth. Many children in low- and middle-income countries have inadequate intakes of these nutrients. We undertook a randomized, placebo controlled double-blind trial in 1000 North Indian children, 6 to 35 months of age
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