所有图片(2)
About This Item
经验公式（希尔记法）:
C9H12N2O6
CAS号:
分子量:
244.20
Beilstein:
754902
MDL编号:
UNSPSC代码:
12352204
PubChem化学物质编号:
推荐产品
等级
reagent grade
产品线
Vetec™
方案
99%
表单
powder
mp
163-167 °C (lit.)
SMILES字符串
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=CC(=O)NC2=O
InChI
1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1
InChI key
DRTQHJPVMGBUCF-XVFCMESISA-N
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一般描述
尿嘧啶核苷是一种嘧啶核苷，由尿嘧啶和容易被大脑吸收的核糖组成。该化合物由哺乳动物从头合成（de novo）。它存在于循环的血液和脑脊髓液中。
生化/生理作用
尿嘧啶核苷是维持细胞功能和能量代谢必不可少的化合物。它有助于多种生物学过程，包括RNA合成、生物膜合成和糖基化。此外，尿嘧啶核苷可用作UDP-葡萄糖的前体分子，UDP-葡萄糖是肝脏中糖原合成和储存的关键成分。此外，研究表明尿嘧啶核苷降低细胞毒性，改善神经生理学功能。它参与调节体内各种正常生理过程，包括心脏-循环、生殖、周围和中枢神经系统、呼吸系统。
法律信息
Vetec is a trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
G P Connolly et al.
Trends in pharmacological sciences, 20(5), 218-225 (1999-06-04)
There are many disorders of pyrimidine metabolism and those that involve an alteration in uridine metabolism have neurological and systemic effects, which provide insights into the biological activity of uridine and its analogues. Studies of the metabolism and actions of
Che C Colpitts et al.
Journal of virology, 87(7), 3640-3654 (2013-01-04)
Entry of enveloped viruses requires fusion of viral and cellular membranes. Fusion requires the formation of an intermediate stalk structure, in which only the outer leaflets are fused. The stalk structure, in turn, requires the lipid bilayer of the envelope
Juma A M Ali et al.
Molecular pharmacology, 83(2), 439-453 (2012-11-29)
African trypanosomes are capable of both pyrimidine biosynthesis and salvage of preformed pyrimidines from the host. However, uptake of pyrimidines in bloodstream form trypanosomes has not been investigated, making it difficult to judge the relative importance of salvage and synthesis
Yuan Zhou et al.
Nucleic acids research, 41(13), 6664-6673 (2013-05-10)
Triplex is emerging as an important RNA tertiary structure motif, in which consecutive non-canonical base pairs form between a duplex and a third strand. RNA duplex region is also often functionally important site for protein binding. Thus, triplex-forming oligonucleotides (TFOs)
Ian E Crandall et al.
Journal of medicinal chemistry, 56(6), 2348-2358 (2013-02-16)
Resistance by Plasmodium falciparum to almost all clinically used antimalarial drugs requires the development of new classes of antimalarials. 6-Iodouridine (15), a novel and potent inhibitor of orotidine 5'-monophosphate decarboxylase (ODCase), exhibited efficacy in a mouse model infected by P.
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