推荐产品
等级
reagent grade
产品线
Vetec™
检测方案
99%
形式
powder
mp
163-167 °C (lit.)
SMILES字符串
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=CC(=O)NC2=O
InChI
1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1
InChI key
DRTQHJPVMGBUCF-XVFCMESISA-N
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一般描述
尿嘧啶核苷是一种嘧啶核苷，由尿嘧啶和容易被大脑吸收的核糖组成。该化合物由哺乳动物从头合成（de novo）。它存在于循环的血液和脑脊髓液中。
生化/生理作用
尿嘧啶核苷是维持细胞功能和能量代谢必不可少的化合物。它有助于多种生物学过程，包括RNA合成、生物膜合成和糖基化。此外，尿嘧啶核苷可用作UDP-葡萄糖的前体分子，UDP-葡萄糖是肝脏中糖原合成和储存的关键成分。此外，研究表明尿嘧啶核苷降低细胞毒性，改善神经生理学功能。它参与调节体内各种正常生理过程，包括心脏-循环、生殖、周围和中枢神经系统、呼吸系统。
法律信息
Vetec is a trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Ian E Crandall et al.
Journal of medicinal chemistry, 56(6), 2348-2358 (2013-02-16)
Resistance by Plasmodium falciparum to almost all clinically used antimalarial drugs requires the development of new classes of antimalarials. 6-Iodouridine (15), a novel and potent inhibitor of orotidine 5'-monophosphate decarboxylase (ODCase), exhibited efficacy in a mouse model infected by P.
Laure Jobert et al.
Molecular cell, 49(2), 339-345 (2012-12-19)
Single-strand-selective monofunctional uracil-DNA glycosylase 1 (SMUG1) is a base excision repair enzyme that removes uracil and oxidised pyrimidines from DNA. We show that SMUG1 interacts with the pseudouridine synthase Dyskerin (DKC1) and colocalizes with DKC1 in nucleoli and Cajal bodies.
G P Connolly et al.
Trends in pharmacological sciences, 20(5), 218-225 (1999-06-04)
There are many disorders of pyrimidine metabolism and those that involve an alteration in uridine metabolism have neurological and systemic effects, which provide insights into the biological activity of uridine and its analogues. Studies of the metabolism and actions of
Che C Colpitts et al.
Journal of virology, 87(7), 3640-3654 (2013-01-04)
Entry of enveloped viruses requires fusion of viral and cellular membranes. Fusion requires the formation of an intermediate stalk structure, in which only the outer leaflets are fused. The stalk structure, in turn, requires the lipid bilayer of the envelope
Yuan Zhou et al.
Nucleic acids research, 41(13), 6664-6673 (2013-05-10)
Triplex is emerging as an important RNA tertiary structure motif, in which consecutive non-canonical base pairs form between a duplex and a third strand. RNA duplex region is also often functionally important site for protein binding. Thus, triplex-forming oligonucleotides (TFOs)
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