推荐产品
等级
reagent grade
产品线
Vetec™
方案
≥97%
沸点
167 °C/0.8 mmHg (lit.)
mp
83-84 °C (lit.)
储存温度
−20°C
SMILES字符串
NCCc1c[nH]cn1
InChI
1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
InChI key
NTYJJOPFIAHURM-UHFFFAOYSA-N
基因信息
human ... HRH1(3269)
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生化/生理作用
内源性 H1 和 H2 组胺受体激动剂；H1 的活化可以使 Ca2+ 移动；H2 的活化可促进神经元中腺苷酸环化酶的活性；活化一氧化氮合成酶；有效的血管舒张剂。
法律信息
Vetec is a trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险分类
Acute Tox. 3 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
靶器官
Respiratory system
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Lena Böhn et al.
The American journal of gastroenterology, 108(5), 634-641 (2013-05-07)
Despite the fact that food and diet are central issues, that concern patients with irritable bowel syndrome (IBS), the current understanding about the association between the intake of certain foods/food groups and the gastrointestinal (GI) symptom pattern, psychological symptoms, and
David P Roberson et al.
Nature neuroscience, 16(7), 910-918 (2013-05-21)
The peripheral terminals of primary sensory neurons detect histamine and non-histamine itch-provoking ligands through molecularly distinct transduction mechanisms. It remains unclear, however, whether these distinct pruritogens activate the same or different afferent fibers. Using a strategy of reversibly silencing specific
Pertti Panula et al.
Nature reviews. Neuroscience, 14(7), 472-487 (2013-06-21)
Histamine acts as a modulatory neurotransmitter in the mammalian brain. It has an important role in the maintenance of wakefulness, and dysfunction in the histaminergic system has been linked to narcolepsy. Recent evidence suggests that aberrant histamine signalling in the
Marieke Smit et al.
The Journal of pharmacology and experimental therapeutics, 348(2), 303-310 (2013-12-07)
The novel once-daily β₂-agonist bronchodilator drug olodaterol has recently been shown to be effective in patients with allergic asthma for >24 hours. An increased cholinergic tone common to these patients may decrease the effectiveness of β₂-agonists. This could provide a
Franziska Glatzer et al.
The Journal of allergy and clinical immunology, 132(6), 1358-1367 (2013-08-13)
Epidermal hyperproliferation resulting in acanthosis is an important clinical observation in patients with atopic dermatitis, and its underlying mechanisms are not completely understood. Because increased levels of histamine are present in lesional skin, we investigated the effect of histamine, especially
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