V900351
5-氟胞嘧啶
Vetec™, reagent grade, 99%
别名:
4-氨基-5-氟-2(1H)-嘧啶酮, 氟胞嘧啶
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关于此项目
经验公式（希尔记法）:
C4H4FN3O
化学文摘社编号:
分子量:
129.09
EC Number:
217-968-7
UNSPSC Code:
41116107
PubChem Substance ID:
Beilstein/REAXYS Number:
127285
MDL number:
InChI key
XRECTZIEBJDKEO-UHFFFAOYSA-N
InChI
1S/C4H4FN3O/c5-2-1-7-4(9)8-3(2)6/h1H,(H3,6,7,8,9)
SMILES string
NC1=NC(=O)NC=C1F
grade
reagent grade
product line
Vetec™
assay
99%
mp
298-300 °C (dec.) (lit.)
storage temp.
2-8°C
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Biochem/physiol Actions
具有抗真菌活性的核苷类似物。 5-FC由胞嘧啶脱氨基酶脱氨，可产生5-氟尿嘧啶，导致RNA密码错编。 5-氟尿嘧啶可抑制DNA和RNA的合成，干扰核糖体蛋白质合成。
Legal Information
Vetec is a trademark of Merck KGaA, Darmstadt, Germany
A D Hartkopf et al.
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To preclinical assess the feasibility of combining oncolytic measles vaccine virus (MeV) with suicide gene therapy for ovarian cancer treatment. We genetically engineered a recombinant MeV armed with a yeast-derived bifunctional suicide gene that encodes for cytosine deaminase and uracil
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Xiaorong Sun et al.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 105(1), 57-63 (2012-09-04)
To investigate whether hypoxia targeted bifunctional suicide gene expression-cytosine deaminase (CD) and uracil phosphoribosyltransferase (UPRT) with 5-FC treatments can enhance radiotherapy. Stable transfectants of R3327-AT cells were established which express a triple-fusion-gene: CD, UPRT and monomoric DsRed (mDsRed) controlled by
Radha Rajasingham et al.
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Cryptococcal meningitis (CM) is the most common form of meningitis in Africa. World Health Organization guidelines recommend 14-d amphotericin-based induction therapy; however, this is impractical for many resource-limited settings due to cost and intensive monitoring needs. A cost-effectiveness analysis was
R Patel
Mayo Clinic proceedings, 73(12), 1205-1225 (1998-12-30)
Traditionally, amphotericin B has been the cornerstone of antifungal treatment. Toxicity, however, is a major dose-limiting factor of amphotericin B deoxycholate. Nevertheless, it continues to have a major role in the treatment of deep-seated mycotic infections. Recently, less nephrotic lipid
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