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1685000

USP

三氟拉嗪盐酸盐

Name: 三氟拉嗪 盐酸盐
Brand: USP

United States Pharmacopeia (USP) Reference Standard

别名:

三氟拉嗪二盐酸盐, 10-[3-(4-甲基哌嗪-1-基)丙基]-2-(三氟甲基)-10H-吩噻嗪二盐酸盐

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About This Item

经验公式（希尔记法）:

C₂₁H₂₄F₃N₃S · 2HCl

CAS号:

440-17-5

分子量:

480.42

Beilstein:

3820024

MDL编号:

MFCD00012656

UNSPSC代码:

41116107

PubChem化学物质编号:

329751398

NACRES:

NA.24

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Sigma-Aldrich

T6062

三氟拉嗪盐酸盐

Y0002259

N -亚硝基二甲胺(NDMA) 溶液

T2000000

三氟拉嗪盐酸盐

Sigma-Aldrich

T8516

三氟拉嗪二盐酸盐

Supelco

PHR1207

甲基乙基酮

Y0002149

Tranexamic acid impurity E

Supelco

1.06014

Ethyl methyl ketone

USP

1082708

二丁基羟基甲苯

USP

1163253

达格列净丙二醇一水合物

USP

1430101

甲基乙基酮

等级

pharmaceutical primary standard

API类

trifluoperazine

制造商/商品名称

USP

mp

243 °C (dec.) (lit.)

应用

pharmaceutical (small molecule)

包装形式

neat

SMILES字符串

Cl[H].Cl[H].CN1CCN(CCCN2c3ccccc3Sc4ccc(cc24)C(F)(F)F)CC1

InChI

1S/C21H24F3N3S.2ClH/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22,23)24;;/h2-3,5-8,15H,4,9-14H2,1H3;2*1H

InChI key

BXDAOUXDMHXPDI-UHFFFAOYSA-N

基因信息

human ... DRD2(1813) , DRD3(1814) , DRD4(1815) , HTR2A(3356) , HTR2C(3358)

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一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Trifluoperazine hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.
Also, for use with USP monographs such as:

Trifluoperazine Hydrochloride Tablets
Trifluoperazine Hydrochloride Injection
Trifluoperazine Oral Solution

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

其他说明

Sales restrictions may apply.

象形图

GHS08,GHS07,GHS09

警示用语：

Danger

危险声明

H302,H319,H336,H341,H372,H410

预防措施声明

P201 - P273 - P301 + P312 + P330 - P305 + P351 + P338 - P308 + P313

危险分类

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Muta. 2 - STOT RE 1 - STOT SE 3

靶器官

Central nervous system, Eyes

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

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Combinatorial therapy with tamoxifen and trifluoperazine effectively inhibits malignant peripheral nerve sheath tumor growth by targeting complementary signaling cascades.

Stephanie N Brosius et al.

Journal of neuropathology and experimental neurology, 73(11), 1078-1090 (2014-10-08)

Chemotherapeutic agents effective against malignant peripheral nerve sheath tumors (MPNSTs) are urgently needed. We recently found that tamoxifen potently impedes xenograft growth. In vitro, tamoxifen inhibits MPNST proliferation and survival in an estrogen receptor-independent manner; these effects are phenocopied by

In vitro selective inhibition of human UDP-glucuronosyltransferase (UGT) 1A4 by finasteride, and prediction of in vivo drug-drug interactions.

Seung Jun Lee et al.

Toxicology letters, 232(2), 458-465 (2014-12-03)

In the present study, we evaluated the inhibitory potentials of finasteride for the major human hepatic UDP-glucuronosyltransferases (UGTs) (UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A9, UGT2B7, and UGT2B15) in vitro using LC-MS/MS by specific marker reactions in human liver microsomes (except for

Repurposing the antipsychotic trifluoperazine as an antimetastasis agent.

Ashleigh Pulkoski-Gross et al.

Molecular pharmacology, 87(3), 501-512 (2015-01-02)

Because cancer cell invasion is a critical determinant of metastasis, targeting invasion is a viable approach to prevent metastasis. Utilizing a novel three-dimensional high-throughput invasion assay, we screened a National Cancer Institute compound library and discovered compounds demonstrating inhibitory effects

Evaluation of the in vitro/in vivo potential of five berries (bilberry, blueberry, cranberry, elderberry, and raspberry ketones) commonly used as herbal supplements to inhibit uridine diphospho-glucuronosyltransferase.

Eu Jin Choi et al.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 72, 13-19 (2014-07-06)

In this study, we evaluated inhibitory potentials of popularly-consumed berries (bilberry, blueberry, cranberry, elderberry, and raspberry ketones) as herbal supplements on UGT1A1, UGT1A4, UGT1A6, UGT1A9, and UGT2B7 in vitro. We also investigated the potential herb-drug interaction via UGT1A1 inhibition by

Evaluation of the in vitro/in vivo drug interaction potential of BST204, a purified dry extract of ginseng, and its four bioactive ginsenosides through cytochrome P450 inhibition/induction and UDP-glucuronosyltransferase inhibition.

Yu Fen Zheng et al.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 68, 117-127 (2014-03-19)

We evaluated the potential of BST204, a purified dry extract of ginseng, to inhibit or induce human liver cytochrome P450 enzymes (CYPs) and UDP-glucuronosyltransferases (UGTs) in vitro to assess its safety. In vitro drug interactions of four bioactive ginsenosides of

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三氟拉嗪盐酸盐