grade
pharmaceutical primary standard
API family
saccharin
manufacturer/tradename
USP
mp
226-229 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
SMILES string
O=C1NS(=O)(=O)c2ccccc12
InChI
1S/C7H5NO3S/c9-7-5-3-1-2-4-6(5)12(10,11)8-7/h1-4H,(H,8,9)
InChI key
CVHZOJJKTDOEJC-UHFFFAOYSA-N
General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Application
Saccharin USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
- Saccharin Sodium Tablets
Biochem/physiol Actions
哺乳动物的甜促味剂。有人提出，果蝇具有葡萄糖特异性甘油味觉受体结合位点。
Analysis Note
These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
Other Notes
Sales restrictions may apply.
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存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
The toxicological effects of saccharin in short-term genotoxicity assays.
D L Arnold et al.
Mutation research, 221(2), 69-132 (1989-09-01)
J Whysner et al.
Pharmacology & therapeutics, 71(1-2), 225-252 (1996-01-01)
Sodium saccharin (NaSac) produces bladder tumors consistently in male rats only after lifetime exposure that begins at birth. NaSac is not metabolized and is negative in most genotoxicity tests. NaSac-induced cell damage and proliferation have been proposed as important factors
R L Anderson
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 26(7), 637-644 (1988-07-01)
An hypothesis is presented of a mechanism for the sodium saccharin (NaS)-associated tumorigenesis of the urinary bladder that occurs in male rats. The ingestion of high doses of NaS is associated with increased urine volume and bladder mass. In rats
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 1607007-200MG | 04061835345564 |