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经验公式（希尔记法）:
C19H21N5O4 · HCl
化学文摘社编号:
分子量:
419.86
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
4303561
产品名称
哌唑嗪 盐酸盐, United States Pharmacopeia (USP) Reference Standard
InChI key
WFXFYZULCQKPIP-UHFFFAOYSA-N
SMILES string
Cl.COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)c4ccco4
InChI
1S/C19H21N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22);1H
grade
pharmaceutical primary standard
API family
prazosin
manufacturer/tradename
USP
application(s)
pharmaceutical (small molecule)
format
neat
Gene Information
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)
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Analysis Note
These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
Application
It was used as an α1-adrenergic receptors antagonist, in a study performed to understand the influence of dopamine on uterine motility of rats in vitro.
General description
Prazosin hydrochloride is an alpha-adrenergic blocking agent, employed as an antihypertensive drug for the treatment of high blood pressure. It lowers the blood pressure by binding to the alpha receptors thereby relaxing the blood vessels.
Other Notes
Sales restrictions may apply.
signalword
Warning
hcodes
Hazard Classifications
Repr. 2 - STOT RE 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Physiologic evaluation of a new antihypertensive agent: prazosin HCl.
Koshy MC
Circulation, 55(3), 533-537 (1977)
Influence of dopamine on rat uterine motility in vitro.
Czerski, A., et al.
Acta Veterinaria Brno, 74.1, 9-15 (2005)
Quantitative analysis of prazosin hydrochloride in pharmaceutical formulation by prazosin potentiometric sensor based on computational investigation.
Faridbod, Farnoush, et al.
International Journal of Electrochemical Science, 5, 653-667 (2010)
Renny Abraham et al.
Canadian journal of physiology and pharmacology, 93(1), 13-21 (2014-11-28)
An extensive amount of research has focused on the development of new pharmacological agents to treat schizophrenia. Varying from person to person, schizophrenia is a heterogeneous disease with symptoms of positive, negative, and cognitive deficits. PRX-07034, a 5-hydroxytryptamine6 (5-HT6) receptor
Guyoung Kwon et al.
Life sciences, 101(1-2), 73-78 (2014-03-04)
Danshensu [3-(3,4-dihydroxyphenyl)-lactic acid], a phenylpropanoid compound isolated from Prunella vulgaris var. lilacina, is a well-known antioxidant. Although its antioxidant activity and cardioprotective effect have been reported, the pharmacological properties of danshensu in the central nervous system remain unclear. We investigated
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