产品名称
Polymyxin B sulfate, United States Pharmacopeia (USP) Reference Standard
SMILES string
[S](=O)(=O)(O)O.N1CCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C1=O)CCO)CCN)CCN)CC(C)C)Cc2ccccc2)CCN)NC(=O)C(NC(=O)C(NC(=O)C(NC=O)CCN)CCO)CCN
InChI
1S/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)
InChI key
HNDFYNOVSOOGDU-UHFFFAOYSA-N
grade
pharmaceutical primary standard
API family
polymyxin
form
powder
manufacturer/tradename
USP
application(s)
USP Biologics
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
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Analysis Note
Application
- Bacitracin and Polymyxin B Sulfate Topical Aerosol®
- Oxytetracycline Hydrochloride and Polymyxin B Sulfate Ointment
- Polymyxin B Sulfate and Trimethoprim Ophthalmic Solution
- Bacitracin Zinc and Polymyxin B Sulfate Ointment
- Polymyxin B Sulfate and Hydrocortisone Otic Solution
- Chloramphenicol and Polymyxin B Sulfate Ophthalmic Ointment
- Oxytetracycline Hydrochloride and Polymyxin B Sulfate Ophthalmic Ointment
General description
Polymyxin B sulfate is a mixture of closely related cyclic polypeptides produced by Bacillus polymyxa. It disrupts the integrity of Gram-negative bacterial membranes by binding to lipopolysaccharides. The USP reference standard is used in microbiological potency assays and system suitability testing.
The USP biologics antibiotics category includes a wide range of antimicrobial agents that are essential in treating bacterial infections. These antibiotics are derived from various natural sources or synthesized to combat specific pathogens effectively. The USP provides comprehensive standards, reference materials, and analytical procedures to ensure the identity, quality, purity, and consistency of antibiotic therapeutics throughout their lifecycle.
The United States Pharmacopeia (USP) provides quality standards for biologics to ensure their safety, efficacy, and quality throughout the manufacturing process. These standards assist manufacturers in adhering to regulatory requirements and help safeguard public health by reducing risks associated with biologics.
Other Notes
Legal Information
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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