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Merck
CN

1392002

USP

6-巯基嘌呤 一水合物

United States Pharmacopeia (USP) Reference Standard

别名:

6-嘌呤硫醇, 6-硫代嘌呤

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关于此项目

经验公式(希尔记法):
C5H4N4S · H2O
化学文摘社编号:
分子量:
170.19
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
4012091
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产品名称

6-巯基嘌呤 一水合物, United States Pharmacopeia (USP) Reference Standard

InChI key

WFFQYWAAEWLHJC-UHFFFAOYSA-N

SMILES string

O.Sc1ncnc2[nH]cnc12

InChI

1S/C5H4N4S.H2O/c10-5-3-4(7-1-6-3)8-2-9-5;/h1-2H,(H2,6,7,8,9,10);1H2

grade

pharmaceutical primary standard

API family

mercaptopurine

manufacturer/tradename

USP

mp

>300 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

Gene Information

human ... PPAT(5471)

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Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Application

Mercaptopurine USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Azathioprine
  • Azathioprine Sodium for Injection
  • Azathioprine Tablets
  • Mercaptopurine
  • Mercaptopurine Tablets

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

pictograms

Skull and crossbonesHealth hazard

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Muta. 2 - Repr. 2

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Qing Qin et al.
Journal of molecular and cellular cardiology, 77, 20-28 (2014-10-07)
Endothelin-1 (ET-1) produced by vascular endothelial cells plays essential roles in the regulation of vascular tone and development of cardiovascular diseases. The objective of this study is to identify novel regulators implicated in the regulation of ET-1 expression in vascular
Balraj Singh et al.
PloS one, 9(10), e109487-e109487 (2014-10-04)
A major obstacle in developing effective therapies against solid tumors stems from an inability to adequately model the rare subpopulation of panresistant cancer cells that may often drive the disease. We describe a strategy for optimally modeling highly abnormal and
Kanika V Choughule et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(8), 1334-1340 (2014-05-16)
Anticancer agent 6-mercaptopurine (6MP) has been in use since 1953 for the treatment of childhood acute lymphoblastic leukemia (ALL) and inflammatory bowel disease. Despite being available for 60 years, several aspects of 6MP drug metabolism and pharmacokinetics in humans are
S Bunda et al.
Oncogene, 34(6), 789-797 (2014-01-29)
Juvenile myelomonocytic leukaemia (JMML) is an aggressive myeloproliferative neoplasm in children characterized by granulocyte macrophage colony-stimulating factor (GM-CSF) hypersensitivity and resistance to chemotherapy. We recently identified c-Cbl (henceforth referred to as Cbl) as a GM-CSF receptor (GMR) responsive protein that
Leanna Cheung et al.
Biochemical pharmacology, 91(1), 97-108 (2014-06-29)
Multidrug resistance protein 4 (MRP4/ABCC4), a member of the ATP-binding cassette (ABC) transporter superfamily, is an organic anion transporter capable of effluxing a wide range of physiologically important signalling molecules and drugs. MRP4 has been proposed to contribute to numerous

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