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Merck
CN

1304016

USP

肝素 钠

United States Pharmacopeia (USP) Reference Standard

别名:

Heparin sodium

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化学文摘社编号:
MDL number:
UNSPSC Code:
41116107
NACRES:
NA.24
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产品名称

肝素 钠, United States Pharmacopeia (USP) Reference Standard

InChI

1S/C26H42N2O37S5.Na/c1-4(30)27-7-9(31)13(6(56-23(7)39)3-55-67(43,44)45)58-26-19(65-70(52,53)54)12(34)16(20(62-26)22(37)38)60-24-8(28-66(40,41)42)15(63-68(46,47)48)14(5(2-29)57-24)59-25-18(64-69(49,50)51)11(33)10(32)17(61-25)21(35)36;/h5-20,23-26,28-29,31-

InChI key

JRTRSJGZMRQDHI-UHFFFAOYSA-N

SMILES string

[Na+].[S](=O)(=O)(NC1C(OC(C(C1O[S](=O)(=O)O)OC4OC(C(C(C4O[S](=O)(=O)O)O)O)C(=O)O)CO)OC2C(OC(C(C2O)O[S](=O)(=O)O)OC3C(OC(C(C3O)NC(=O)C)O)CO[S](=O)(=O)O)C(=O)O)O

grade

pharmaceutical primary standard

API family

heparin

form

powder

manufacturer/tradename

USP

application(s)

USP Biologics
pharmaceutical (small molecule)

format

neat

shipped in

dry ice

storage temp.

−20°C

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Application

Heparin sodium for assays USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Anticoagulant Heparin Solution
  • Heparin Sodium
  • Antithrombin III Human
  • Protamine Sulfate

Disclaimer

Sales restrictions may apply.

General description

Heparin sodium for assays is an unfractionated heparin (UFH) standard used for quantitative analysis of anticoagulant activity. It supports identity, potency, and impurity testing through validated chromatographic and enzymatic methods in parenteral formulations.

The USP biologics carbohydrates category includes a variety of carbohydrate-based substances that are essential in the development and manufacturing of therapeutic products. These carbohydrates play crucial roles in biological processes and are often utilized as excipients, stabilizers, or active ingredients in pharmaceuticals. The USP provides comprehensive standards, reference materials, and analytical procedures to ensure the identity, quality, purity, and consistency of carbohydrate therapeutics throughout their lifecycle.

The United States Pharmacopeia (USP) provides quality standards for biologics to ensure their safety, efficacy, and quality throughout the manufacturing process. These standards assist manufacturers in adhering to regulatory requirements and help safeguard public health by reducing risks associated with biologics.

Other Notes

Heparin Sodium is the sodium salt of sulfated glycosaminoglycans present in mammalian tissues, which has properties that can prevent blood clotting. It is usually obtained from the intestinal mucosa or other suitable tissues of domestic mammals used for f
Heparin Sodium is the sodium salt of sulfated glycosaminoglycans present in mammalian tissues, which has properties that can prevent blood clotting. It is usually obtained from the intestinal mucosa or other suitable tissues of domestic mammals used for food by humans. Heparin sodium is commonly administered for the prevention of deep venous thrombosis in both medical and surgical patients. Heparin sodium for assays USP reference standard is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
This product is part of the USP Biologics program.

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number

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Anticoagulant Heparin Solution
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 2194-2194 (2019)
Antithrombin III Human
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 41(5), 355-355 (2022)
Heparin-induced hyperkalemia
Edes T E and Sunderrajan E V
Archives of Internal Medicine (1985)
?208? Anti-factor Xa and anti-factor IIa assays for unfractionated and low molecular weight heparins
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 38(2), 6611-6611 (2020)
Protamine Sulfate
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 42(1), 3757-3757 (2017)

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