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等级
pharmaceutical primary standard
API类
fulvestrant
制造商/商品名称
USP
应用
pharmaceutical (small molecule)
包装形式
neat
储存温度
2-8°C
SMILES字符串
[H][C@]12CC[C@]3(C)[C@@H](O)CC[C@@]3([H])[C@]1([H])[C@H](CCCCCCCCCS(=O)CCCC(F)(F)C(F)(F)F)Cc4cc(O)ccc24
InChI
1S/C32H47F5O3S/c1-30-17-15-26-25-12-11-24(38)21-23(25)20-22(29(26)27(30)13-14-28(30)39)10-7-5-3-2-4-6-8-18-41(40)19-9-16-31(33,34)32(35,36)37/h11-12,21-22,26-29,38-39H,2-10,13-20H2,1H3/t22-,26-,27+,28+,29-,30+,41?/m1/s1
InChI key
VWUXBMIQPBEWFH-WCCTWKNTSA-N
基因信息
human ... ESR1(2099) , ESR2(2100)
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一般描述
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.
应用
- Targeted Radiation Drug for Breast Cancer: Fulvestrant was utilized in fluorocarbon nanoparticles combined with iodine-131, demonstrating potential as a targeted radiation drug for endocrine therapy in breast cancer treatment, enhancing the applicability of Fulvestrant in advanced therapeutic approaches (Zhi et al., 2024).
- Pharmacological Insights: A comprehensive review discussed novel oral selective estrogen receptor degraders, including Fulvestrant, detailing their mechanism and efficacy in breast cancer treatment, providing crucial insights for ongoing pharmaceutical research and development (Guglielmi et al., 2024).
- Quantification in Clinical Practice: Development of an LC-MS/MS method for the simultaneous quantification of four hormone therapy drugs, including Fulvestrant, in breast cancer patients supports its clinical application and monitoring, ensuring effective patient management and therapy optimization (Mansour et al., 2024).
生化/生理作用
氟维司群（ICI 182,780）是一种选择性雌激素受体下调剂（SERD）。氟维司群是一种具有高亲和力的雌激素受体拮抗剂。IC50 = 0.29 nM。氟维司群是第一种“纯”抗雌激素，在体外和体内均无激动活性。
分析说明
These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
其他说明
Sales restrictions may apply.
警示用语：
Danger
危险声明
危险分类
Aquatic Chronic 1 - Lact. - Repr. 1B
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
监管及禁止进口产品
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