推荐产品
生物来源
synthetic
Agency
USP
API类
fingolimod
形式
powder
制造商/商品名称
USP
储存条件
protect from light
颜色
white
溶解性
DMSO: soluble
ethyl acetate: soluble
water: soluble
应用
pharmaceutical
储存温度
2-8°C
InChI
1S/C19H33NO2.ClH/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-22;/h9-12,21-22H,2-8,13-16,20H2,1H3;1H
InChI key
SWZTYAVBMYWFGS-UHFFFAOYSA-N
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一般描述
Fingolimod Hydrochloride (fingolimod HCl), an S1P-receptor modulator, belongs to the class of synthetic glucocorticoid steroid drugs.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets, have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets, have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
应用
Fingolimod Hydrochloride USP reference standard may be used to quantify the analyte in gel, capsule and other pharmaceutical formulations, active pharmaceutical ingredient (API) and pharmaceutical dosage forms by liquid chromatography (LC) based techniques.
生化/生理作用
FTY720是一种免疫调节药物以及1-磷酸鞘氨醇（S1P）受体的调节剂。 鞘氨醇激酶对FTY270的磷酸化可导致S1P1R的内化，从而螯合淋巴结中的淋巴细胞，阻止它们参与自身免疫反应。 临床上，它已被批准用于治疗多发性硬化症（MS）。研究显示其可通过抑制S1PR阻断和逆转紫杉醇诱导的化疗诱导的周围神经病变（CIPN），并可抑制小鼠脑海马中组蛋白脱乙酰酶的活性，从而调节记忆。
分析说明
These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
其他说明
Sales restrictions may apply.
警示用语：
Warning
危险声明
预防措施声明
危险分类
STOT RE 2
靶器官
Immune system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
A randomized, open-label study assessing the bioequivalence of two formulations of Fingolimod 0.5 mg in healthy subjects
Tanguay M, et al.
AAPS Open, 4(1), 3-3 (2018)
Fingolimod Hydrochloride
Fingolimod Hydrochloride USP Monograph; USP42-NF37:United States Pharmacopeia and National Formulary
United States Pharmacopeia, 43(6)(1), 1849-1849 (2020)
Rapid determination of fingolimod hydrochloride-related Substances and degradation products in API and pharmaceutical dosage forms by use of a stability-indicating UPLC method
Rajan N and Basha KA
Chromatographia, 77(21-22), 1545-1552 (2014)
Solubility of dexamethasone in supercritical carbon dioxide
Chim RB, et al.
Journal of Chemical and Engineering Data, 57(12), 3756-3760 (2012)
Sphingosine 1-phosphate receptor 1 as a useful target for treatment of multiple sclerosis
Chiba K and Adachi K
Pharmaceuticals (Basel, Switzerland), 5(5), 514-528 (2012)
相关内容
High-Performance Liquid Chromatography method ensures total chromatographic purity analysis of Fingolimod Hydrochloride, offering rapid accuracy.
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