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Merck
CN

1260001

USP

炔雌醇

United States Pharmacopeia (USP) Reference Standard

别名:

17α-乙炔基雌二醇, 17α-乙炔基-1,3,5(10)-雌甾三烯-1,17β-二醇, 19-去甲-1,3,5(10),17α-雌甾三烯-20-炔-3,17-二醇, 炔雌醇

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关于此项目

经验公式(希尔记法):
C20H24O2
化学文摘社编号:
分子量:
296.40
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
2419975
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grade

pharmaceutical primary standard

API family

ethinyl estradiol

manufacturer/tradename

USP

mp

182-183 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

[H][C@]12CC[C@@]3(C)[C@@]([H])(CC[C@@]3(O)C#C)[C@]1([H])CCc4cc(O)ccc24

InChI

1S/C20H24O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,5,7,12,16-18,21-22H,4,6,8-11H2,2H3/t16-,17-,18+,19+,20+/m1/s1

InChI key

BFPYWIDHMRZLRN-SLHNCBLASA-N

Gene Information

human ... ESR1(2099)

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Ethinyl estradiol USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Desogestrel and Ethinyl Estradiol Tablets
  • Drospirenone and Ethinyl Estradiol Tablets
  • Ethinyl Estradiol
  • Ethinyl Estradiol Tablets
  • Ethynodiol Diacetate and Ethinyl Estradiol Tablets
  • Levonorgestrel and Ethinyl Estradiol Tablets
  • Norethindrone Acetate and Ethinyl Estradiol Tablets

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.


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Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 1 - Carc. 2 - Repr. 1A

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

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Tomás Cajthaml et al.
Environmental pollution (Barking, Essex : 1987), 157(12), 3325-3335 (2009-07-25)
Natural estrogens such as estrone, 17beta-estradiol, estriol, and the particularly recalcitrant synthetic estrogen 17alpha-ethinylestradiol used as oral contraceptive, accumulate in the environment and may give rise to health problems. The processes participating in their removal from soil, wastewater, water-sediments, groundwater-aquifer
Hongjian Zhang et al.
Clinical pharmacokinetics, 46(2), 133-157 (2007-01-27)
17alpha-Ethinylestradiol (EE) is widely used as the estrogenic component of oral contraceptives (OC). In vitro and in vivo metabolism studies indicate that EE is extensively metabolised, primarily via intestinal sulfation and hepatic oxidation, glucuronidation and sulfation. Cytochrome P450 (CYP)3A4-mediated EE
Robert W Flick et al.
Aquatic toxicology (Amsterdam, Netherlands), 152, 353-360 (2014-05-13)
Vitellogenin is frequently used as a biomarker of exposure to environmental estrogens due to its specificity and sensitivity. Appropriate incorporation of this biomarker into environmental monitoring and assessment necessitates evaluation of its critical performance parameters. In this study, we characterize



全球贸易项目编号

货号GTIN
1260001-150MG04061838723796