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Merck
CN

1173508

USP

去羟米松

United States Pharmacopeia (USP) Reference Standard

别名:

9-氟-11β,21-二羟基-16α-甲基孕甾-1,4-二烯-3,20-二酮

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关于此项目

经验公式（希尔记法）:
C22H29FO4
化学文摘社编号:
382-67-2
分子量:
376.46
UNSPSC Code:
41116107
NACRES:
NA.24
MDL number:
MFCD00083301

主要文件

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产品名称

去羟米松, United States Pharmacopeia (USP) Reference Standard

InChI

1S/C22H29FO4/c1-12-8-16-15-5-4-13-9-14(25)6-7-21(13,3)22(15,23)18(27)10-20(16,2)19(12)17(26)11-24/h6-7,9,12,15-16,18-19,24,27H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,18+,19-,20+,21+,22+/m1/s1

SMILES string

[H][C@@]12C[C@@H](C)[C@H](C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]3(F)[C@@]2([H])CCC4=CC(=O)C=C[C@]34C

InChI key

VWVSBHGCDBMOOT-IIEHVVJPSA-N

biological source

synthetic

agency

USP

vapor pressure

<0.0000001 kPa ( 25 °C)

API family

desoximetasone

form

powder

packaging

pkg of 200 mg

manufacturer/tradename

USP

storage condition

protect from light

color

white

solubility

acetone: freely soluble
alcohol: freely soluble
benzene: slightly soluble
chloroform: freely soluble
ether: slightly soluble
water: insoluble

application(s)

pharmaceutical (small molecule)

Gene Information

human ... NR3C1(2908)

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相关类别

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Application

Desoximetasone USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Desoximetasone Cream
  • Desoximetasone Gel
  • Desoximetasone Ointment
  • Dexamethasone

General description

Desoximetasone is a topical corticosteroid known to modify the functions of leukocytes that are mainly responsible for skin infections, inflammation and allergies.

Other Notes

Sales restrictions may apply.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2 - Skin Sens. 1

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Development and Validation of RP-HPLC Method for Desoximetasone in Bulk and Cream Formulation
Gorle A, et al.
Journal of Drug Delivery and Therapeutics, 9(3), 154-159 (2019)
Topical corticosteroids: mechanisms of action.
Kragballe, K
Acta Dermato-Venereologica. Supplementum, 151(3), 7-7 (1989)
Desoximetasone USP Monograph
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 44(2), 1272-1272 (2020)
S Vladimirov et al.
Journal of pharmaceutical and biomedical analysis, 14(8-10), 947-950 (1996-06-01)
The proposed method is based on coloured hydrazone formation with 1,4-dihydrazinophthalazine as a reagent. Heating at 85 degrees C for 2 h was found necessary to ensure optimal hydrazone formation in the presence of hydrochloric acid. The yellow hydrazone product

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