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安全信息

1173508

USP

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United States Pharmacopeia (USP) Reference Standard

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别名:
9-氟-11β,21-二羟基-16α-甲基孕甾-1,4-二烯-3,20-二酮
经验公式（希尔记法）:
C22H29FO4
CAS号:
382-67-2
分子量:
376.46
MDL编号:
MFCD00083301
UNSPSC代码:
41116107
NACRES:
NA.24

生物来源

synthetic

Agency

USP

蒸汽压

<0.0000001 kPa ( 25 °C)

API类

desoximetasone

形式

powder

包装

pkg of 200 mg

制造商/商品名称

USP

储存条件

protect from light

颜色

white

溶解性

acetone: freely soluble
alcohol: freely soluble
benzene: slightly soluble
chloroform: freely soluble
ether: slightly soluble
water: insoluble

应用

pharmaceutical (small molecule)

SMILES字符串

[H][C@@]12C[C@@H](C)[C@H](C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]3(F)[C@@]2([H])CCC4=CC(=O)C=C[C@]34C

InChI

1S/C22H29FO4/c1-12-8-16-15-5-4-13-9-14(25)6-7-21(13,3)22(15,23)18(27)10-20(16,2)19(12)17(26)11-24/h6-7,9,12,15-16,18-19,24,27H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,18+,19-,20+,21+,22+/m1/s1

InChI key

VWVSBHGCDBMOOT-IIEHVVJPSA-N

基因信息

human ... NR3C1(2908)

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一般描述

Desoximetasone is a topical corticosteroid known to modify the functions of leukocytes that are mainly responsible for skin infections, inflammation and allergies.

应用

Desoximetasone is used as an analytical standard for the determination of the analyte in pharmaceutical dosage forms by various analytical techniques.

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

Sales restrictions may apply.

相关产品

产品编号
说明
价格

象形图

Health hazardExclamation mark
GHS08,GHS07

警示用语：

Warning

危险分类

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

靶器官

Respiratory system

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

监管及禁止进口产品

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Development and Validation of RP-HPLC Method for Desoximetasone in Bulk and Cream Formulation
Gorle A, et al.
Journal of Drug Delivery and Therapeutics, 9(3), 154-159 (2019)
Topical corticosteroids: mechanisms of action.
Kragballe, K
Acta Dermato-Venereologica. Supplementum, 151(3), 7-7 (1989)
Desoximetasone USP Monograph
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 44(2), 1272-1272 (2020)
S Vladimirov et al.
Journal of pharmaceutical and biomedical analysis, 14(8-10), 947-950 (1996-06-01)
The proposed method is based on coloured hydrazone formation with 1,4-dihydrazinophthalazine as a reagent. Heating at 85 degrees C for 2 h was found necessary to ensure optimal hydrazone formation in the presence of hydrochloric acid. The yellow hydrazone product

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