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文件

安全信息

安全和法规

1158504

USP

环孢霉素

Name: 环孢霉素
Brand: USP

United States Pharmacopeia (USP) Reference Standard

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别名:

环孢菌素A, 抗生素S 7481F1, 环孢霉素

经验公式（希尔记法）:

C₆₂H₁₁₁N₁₁O₁₂

CAS号:

59865-13-3

分子量:

1202.61

Beilstein:

3647785

MDL编号:

MFCD00274558

UNSPSC代码:

41116107

PubChem化学物质编号:

329749492

NACRES:

NA.24

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Sigma-Aldrich

30024

环孢菌素A

Supelco

PHR1092

环孢霉素

C2163000

环孢素

Sigma-Aldrich

SML1018

环孢素A，即用型溶液

Supelco

32425

环孢菌素A

Supelco

C-093

环孢菌素A 溶液

Sigma-Aldrich

C1832

环孢菌素A

Y0002292

环孢菌素 A，系统适用性测试标准品

USP

1158650

拆分用环孢霉素混合物

Sigma-Aldrich

C3662

环孢菌素A

等级

pharmaceutical primary standard

API类

cyclosporine

制造商/商品名称

USP

应用

pharmaceutical (small molecule)

格式

neat

储存温度

−20°C

SMILES字符串

CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C

InChI

1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1

InChI key

PMATZTZNYRCHOR-CGLBZJNRSA-N

基因信息

human ... PPIA(5478)

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一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Cyclosporine USP reference standard is meant for specified quality tests and assays.

Also used to prepare standard solutions for the assay, identification and impurity analysis according to the given below monographs of United States Pharmacopeia (USP):

Cyclosporine
Cyclosporine Injection
Cyclosporine Oral Solution
Cyclosporine Capsules
Cyclosporine Compounded Ophthalmic Solution, Veterinary

生化/生理作用

一种具有强大的免疫抑制特性的真菌代谢物。它通过形成抑制钙调神经磷酸酶（蛋白磷酸酶 2B）的环孢菌素A−亲环蛋白复合物来抑制 T 细胞受体的信号转导途径。抑制由白介素1α、脂多糖和TNFα诱导的一氧化氮合成。阻止线粒体释放细胞色素 c。

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

其他说明

Sales restrictions may apply.

1158650

拆分用环孢霉素混合物, United States Pharmacopeia (USP) Reference Standard

象形图

GHS08,GHS07

警示用语：

Danger

危险声明

H302,H350,H360FD

预防措施声明

P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405

危险分类

Acute Tox. 4 Oral - Carc. 1B - Repr. 1B

WGK

WGK 3

法规信息

监管及禁止进口产品

分析证书(COA)

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