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Merck
CN

1091221

USP

Captopril disulfide

United States Pharmacopeia (USP) Reference Standard

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别名:
1,1′-[Dithiobis[(2S)-2-methyl-1-oxo-3,1-propanediyl]]bis-L-proline
经验公式(希尔记法):
C18H28N2O6S2
CAS号:
分子量:
432.55
UNSPSC代码:
41116107
NACRES:
NA.24

等级

pharmaceutical primary standard

API类

captopril

制造商/商品名称

USP

应用

pharmaceutical (small molecule)

格式

neat

储存温度

2-8°C

InChI

1S/C18H28N2O6S2/c1-11(15(21)19-7-3-5-13(19)17(23)24)9-27-28-10-12(2)16(22)20-8-4-6-14(20)18(25)26/h11-14H,3-10H2,1-2H3,(H,23,24)(H,25,26)/t11-,12?,13+,14+/m1/s1

InChI key

ZWKRXBCJAUKDCI-KRCVMZOZSA-N

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一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Captopril disulfide USP reference standard suitable for use in specified USP compendial tests and assays.

Also used to prepare standard, system suitability stock, and system suitability solution for assay and impurity analysis according to the given below monographs of United States Pharmacopeia (USP):
  • Captopril Tablets
  • Captopril
  • Captopril and Hydrochlorothiazide Tablets

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

Sales restrictions may apply.

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


分析证书(COA)

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Managing hypertension in patients with renal disease.
J G Porush
Journal of the National Medical Association, 76 Suppl, 24-32 (1984-07-01)
Participation of kinins or prostaglandins in SQ 14,551-induced immediate decrease of blood pressure in anesthetized dogs.
N O'Hara et al.
Japanese journal of pharmacology, 33(2), 485-488 (1983-04-01)
Electrochemical reduction of disulfides.
H Kadin
Methods in enzymology, 143, 257-264 (1987-01-01)
E Ivashkiv
Journal of pharmaceutical sciences, 73(10), 1427-1430 (1984-10-01)
Captopril disulfides and the drug covalently bound to proteins were reduced with tri-n-butylphosphine. After sample purification on an XAD-2 column, captopril was treated with 1-(7-dimethylamino)-4-methyl-2-oxo-2H -1-benzopyran-3-yl)-1H-pyrrole-2,5-dione to form a fluorescent derivative. After acidification, the fluorescent derivative was extracted into toluene
Captopril and HydrochlorothiazideTablets
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 43(4), 737-737 (2019)

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