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经验公式（希尔记法）:
C19H17Cl3N2S · HNO3
化学文摘社编号:
分子量:
474.79
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
InChI key
ZHPWRQIPPNZNML-UHFFFAOYSA-N
SMILES string
ClC1=C(C(Cl)=CC=C1)SC(CCC2=CC=C(Cl)C=C2)CN3C=CN=C3.O[N+]([O-])=O
InChI
1S/C19H17Cl3N2S.HNO3/c20-15-7-4-14(5-8-15)6-9-16(12-24-11-10-23-13-24)25-19-17(21)2-1-3-18(19)22;2-1(3)4/h1-5,7-8,10-11,13,16H,6,9,12H2;(H,2,3,4)
grade
pharmaceutical primary standard
API family
butoconazole
manufacturer/tradename
USP
application(s)
pharmaceutical (small molecule)
format
neat
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General description
Butoconazole nitrate (BN) is a imidazole used as an antifungal agent.
Application
Butoconazole nitrate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.
Also, for use with USP monograph such as Butoconazole Nitrate Vaginal Cream.
Also, for use with USP monograph such as Butoconazole Nitrate Vaginal Cream.
Analysis Note
These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
Other Notes
Sales restrictions may apply.
Hazard Classifications
Acute Tox. 4 Oral
signalword
Warning
hcodes
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
J B Jacobson et al.
Acta obstetricia et gynecologica Scandinavica, 64(3), 241-244 (1985-01-01)
The continuously increasing incidence of vulvovaginal candidiasis necessitated a search for novel therapeutic modalities. Butoconazole nitrate (BN) a new imidazole, has been singled out for clinical studies since, in experimental vaginal candidiasis, it proved more effective than either miconazole nitrate
Meng-meng Jia et al.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 34(3), 431-436 (2014-06-19)
A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the determination of butoconazole in human plasma. Human plasma samples of 0.2 μL were pretreated by a single step protein precipitation procedure and analyzed using a high performance
P A Maloley et al.
DICP : the annals of pharmacotherapy, 24(2), 143-144 (1990-02-01)
A 54-year-old woman with a 19-year history of rheumatoid arthritis developed life-threatening thrombocytopenia one week after beginning butoconazole therapy for a vaginal yeast infection. This was complicated by upper gastrointestinal hemorrhage that probably resulted from ibuprofen and methotrexate therapy. Sepsis
Ginekologia polska, 80(4), 303-311 (2009-06-11)
Vulvovaginal infection is the most common cause of gynecological problems in sexually active women. Knowledge about pharmacological properties of drugs used in treatment vulvovaginal candidiasis allows for tailoring therapy to each patient. 2% butoconazole nitrate vaginal cream is modern and
Drugs for vulvovaginal candidiasis.
The Medical letter on drugs and therapeutics, 43(1095), 3-4 (2001-01-11)
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