InChI key
ZDYJWDIWLRZXDB-UHFFFAOYSA-N
InChI
1S/C14H8Cl4/c15-10-7-5-9(6-8-10)13(14(17)18)11-3-1-2-4-12(11)16/h1-8H
grade
analytical standard
packaging
ampule of 50 mg
manufacturer/tradename
Chem Service, Inc. N-12707-50MG
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
format
neat
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Anna A Kasperlik-Zaluska et al.
Journal of experimental therapeutics & oncology, 5(2), 125-132 (2006-02-14)
Our study aimed at evaluation of the relations between the plasma levels of mitotane (o,p'-DDD) and its metabolites, o,p'-DDA and o,p'-DDE, and the efficacy of Mitotane therapy during a long-term follow-up. Eighteen patients, aged 11 to 70 years, were included
Ilse G Hermsen et al.
The Journal of clinical endocrinology and metabolism, 96(6), 1844-1851 (2011-04-08)
In patients with adrenocortical carcinoma (ACC) mitotane activity has been suggested to depend on plasma levels 14 mg/liter or greater and metabolite formation. The study was performed to confirm the correlation of the currently used mitotane (o,p'DDD) threshold of 14
W Foster et al.
The Journal of clinical endocrinology and metabolism, 85(8), 2954-2957 (2000-08-18)
Man-made chemicals that have been shown to modulate endocrine function in animal models, so-called "endocrine disrupters", are suspected to play a role in the development of male reproductive tract abnormalities and neurobehaviroal deficits in children. However in utero exposure to
Diana M Papoulias et al.
Environmental health perspectives, 111(1), 29-32 (2003-01-08)
Despite being banned in many countries, dichlorodiphenyltrichloroethane (DDT) and its metabolites dichlorodiphenyldichloroethylene (DDE) and dichlorodiphenyldichloroethane (DDD) continue to be found in fish tissues at concentrations of concern. Like o,p -DDT, o,p -DDE is estrogenic and is believed to exert its
R Benecke et al.
European journal of clinical pharmacology, 41(3), 259-261 (1991-01-01)
Mitotane (o,p'-DDD) can be used for the treatment of various adrenocortical diseases such as Cushing's syndrome, but the usual doses of 6-8 g per day are often associated with severe adverse effects. This paper reports the results of much lower
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