推荐产品
product name
Cyano HPLC 色谱柱 ®, 5 μm particle size, L × I.D. 25 cm × 4 mm
物料
stainless steel column
质量水平
Agency
suitable for USP L10
产品线
Discovery®
特点
endcapped
制造商/商品名称
Discovery®
包装
1 ea of
标记范围
4.5% Carbon loading
参数
≤70 °C temp. range
400 bar pressure (5801 psi)
技术
HPLC: suitable
LC/MS: suitable
长度 × 内径
25 cm × 4 mm
表面积
200 m2/g
表面覆盖度
3.5 μmol/m2
杂质
<10 ppm metals
基质
silica gel, high purity, spherical base material
fully porous particle
基质活性基团
cyano phase
粒径
5 μm
孔径
180 Å
operating pH range
2-8
应用
food and beverages
分离技术
hydrophilic interaction (HILIC)
normal phase
reversed phase
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相关类别
特点和优势
- 低疏水性可实现对疏水性化合物的快速洗脱
- 分析强碱性化合物具有优良的峰形和保留性能
- 对极性化合物具有较强的保留能力
- 独特的选择性
- 保留时间显著小于 C18 柱（通常流动相中所需有机相比例更低）
- 稳定性好、低流失，适用于 LC-MS 分析
- 与高含水量的流动相兼容
法律信息
Discovery is a registered trademark of Merck KGaA, Darmstadt, Germany
法规信息
新产品
Graciela B Arhancet et al.
Journal of medicinal chemistry, 53(16), 5970-5978 (2010-08-03)
A new 1,4-dihydropyridine 5a, containing a cyano group at the C3 position, was recently reported to possess excellent mineralocorticoid receptor (MR) antagonist in vitro potency and no calcium channel-blocker (CCB) activity. In the present study, we report the structure-activity relationships
K Umekawa et al.
Japanese journal of pharmacology, 84(1), 7-15 (2000-10-24)
We describe the pharmacological characteristics of SM-19712 (4-chloro-N-[[(4-cyano-3-methyl-1-phenyl-1H-pyrazol-5-yl)amino]carbonyl] benzenesulfonamide, monosodium salt). SM-19712 inhibited endothelin converting enzyme (ECE) solubilized from rat lung microsomes with an IC50 value of 42 nM and, at 10 - 100 microM, had no effect on other
Srdan Verstovsek et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 14(3), 788-796 (2008-02-05)
The discovery of an activating somatic mutation in codon 617 of the gene encoding the Janus kinase (JAK)-2 (JAK2 V617F) in patients with myeloproliferative disorders has opened new avenues for the development of targeted therapies for these malignancies. However, no
Christophe Morisseau et al.
Analytical biochemistry, 414(1), 154-162 (2011-03-05)
The microsomal epoxide hydrolase (mEH) plays a significant role in the metabolism of numerous xenobiotics. In addition, it has a potential role in sexual development and bile acid transport, and it is associated with a number of diseases such as
Arnout Voet et al.
ChemMedChem, 8(4), 644-651 (2013-02-26)
Unraveling the mechanisms involved in castration- and therapy-resistant prostate cancer has led to a renewed interest in androgen receptor (AR)-targeted therapeutics. Anti-androgens that block the activity of the AR therefore remain a valid therapeutic option. However, they must be more
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