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59356-U

Discovery^® Cyano (5 µm) HPLC Columns

Name: Discovery<SUP>&#174;</SUP> Cyano (5 µm) HPLC Columns
Brand: SUPELCO
Price: 6218.64 CNY
Availability: InStock

L × I.D. 15 cm × 4.6 mm, HPLC Column

别名:

氰基键合相色谱柱

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1 EA

¥6,218.64

国内现货，预计发货时间2025年4月27日详情

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1 EA

¥6,218.64

About This Item

UNSPSC代码:

41115700

eCl@ss:

32110501

NACRES:

SB.52

¥6,218.64

国内现货，预计发货时间2025年4月27日详情

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此商品	569255U	569251U	569253U
59356U Cyano HPLC 色谱柱 ^®	569255U Discovery^® HS C18 高效液相色谱柱	569251U Discovery^® HS C18 高效液相色谱柱	569253U Discovery^® HS C18 高效液相色谱柱
particle size 5 μm	particle size 3 μm	particle size 3 μm	particle size 3 μm
matrix silica gel, high purity, spherical base material, fully porous particle	matrix silica gel, high purity, spherical particle platform, fully porous particle	matrix silica gel, high purity, spherical particle platform, fully porous particle	matrix silica gel, high purity, spherical particle platform, fully porous particle
separation technique hydrophilic interaction (HILIC), reversed phase, normal phase	separation technique reversed phase	separation technique reversed phase	separation technique reversed phase
matrix active group cyano phase	matrix active group C18 (octadecyl) phase	matrix active group C18 (octadecyl) phase	matrix active group C18 (octadecyl) phase
technique(s) HPLC: suitable, LC/MS: suitable	technique(s) HPLC: suitable, LC/MS: suitable	technique(s) HPLC: suitable, LC/MS: suitable	technique(s) HPLC: suitable, LC/MS: suitable
pore size 180 Å	pore size 120 Å	pore size 120 Å	pore size 120 Å

一般描述

Discovery^® Cyano HPLC色谱柱用于保留和分离强碱性分析物（包括季铵盐），具有出色峰形。

应用

Discovery® Cyano HPLC columns provide a lower hydrophobicity than C18 or C8 and different selectivity. Typical applications are the separation of Flavonoids, Phenols, Phthalates, Steroids, Sulfonamides, Oils and Alcohols.

特点和优势

低疏水性可实现对疏水性化合物的快速洗脱
分析强碱性化合物具有优良的峰形和保留性能
对极性化合物具有较强的保留能力
独特的选择性
保留时间显著小于 C18 柱（通常流动相中所需有机相比例更低）
稳定性好、低流失，适用于 LC-MS 分析
与高含水量的流动相兼容

法律信息

Discovery is a registered trademark of Merck KGaA, Darmstadt, Germany

55205

直连式保护柱套, Direct-Connect, for use with Supelguard cartridge (2 cm L. x 3 to 4.6 mm I.D.)

59586-U

Discovery^®氰基 Supelguard 保护柱芯, 5 μm particle size, L × I.D. 2 cm × 4 mm

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Discovery of novel cyanodihydropyridines as potent mineralocorticoid receptor antagonists.

Graciela B Arhancet et al.

Journal of medicinal chemistry, 53(16), 5970-5978 (2010-08-03)

A new 1,4-dihydropyridine 5a, containing a cyano group at the C3 position, was recently reported to possess excellent mineralocorticoid receptor (MR) antagonist in vitro potency and no calcium channel-blocker (CCB) activity. In the present study, we report the structure-activity relationships

Receptor localization, native tissue binding and ex vivo occupancy for centrally penetrant P2X7 antagonists in the rat.

S L Able et al.

British journal of pharmacology, 162(2), 405-414 (2010-09-16)

The P2X7 receptor is implicated in inflammation and pain and is therefore a potential target for therapeutic intervention. Here, the development of a native tissue radioligand binding, localization and ex vivo occupancy assay for centrally penetrant P2X7 receptor antagonists is

Calcilytic compounds: potent and selective Ca2+ receptor antagonists that stimulate secretion of parathyroid hormone.

E F Nemeth et al.

The Journal of pharmacology and experimental therapeutics, 299(1), 323-331 (2001-09-19)

Despite the discovery of many ions and molecules that activate the Ca2+ receptor, there are no known ligands that block this receptor. Reported here are the pharmacodynamic properties of a small molecule, NPS 2143, which acts as an antagonist at

Pharmacological characterization of a novel sulfonylureid-pyrazole derivative, SM-19712, a potent nonpeptidic inhibitor of endothelin converting enzyme.

K Umekawa et al.

Japanese journal of pharmacology, 84(1), 7-15 (2000-10-24)

We describe the pharmacological characteristics of SM-19712 (4-chloro-N-[[(4-cyano-3-methyl-1-phenyl-1H-pyrazol-5-yl)amino]carbonyl] benzenesulfonamide, monosodium salt). SM-19712 inhibited endothelin converting enzyme (ECE) solubilized from rat lung microsomes with an IC50 value of 42 nM and, at 10 - 100 microM, had no effect on other

WP1066, a novel JAK2 inhibitor, suppresses proliferation and induces apoptosis in erythroid human cells carrying the JAK2 V617F mutation.

Srdan Verstovsek et al.

Clinical cancer research : an official journal of the American Association for Cancer Research, 14(3), 788-796 (2008-02-05)

The discovery of an activating somatic mutation in codon 617 of the gene encoding the Janus kinase (JAK)-2 (JAK2 V617F) in patients with myeloproliferative disorders has opened new avenues for the development of targeted therapies for these malignancies. However, no

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Discovery^® Cyano (5 µm) HPLC Columns

L × I.D. 15 cm × 4.6 mm, HPLC Column

选择尺寸