产品名称
Discovery ® C8 HPLC 色谱柱, 5 μm particle size, L × I.D. 25 cm × 4.6 mm
material
stainless steel column
agency
suitable for USP L7
product line
Discovery®
feature
endcapped
manufacturer/tradename
Discovery®
packaging
1 ea of
extent of labeling
7.5% Carbon loading
parameter
≤70 °C temp. range
400 bar pressure (5801 psi)
technique(s)
HPLC: suitable
LC/MS: suitable
L × I.D.
25 cm × 4.6 mm
surface area
200 m2/g
surface coverage
3.4 μmol/m2
impurities
<10 ppm metals
matrix
silica gel, high purity, spherical base material
fully porous particle
matrix active group
C8 (octyl) phase
particle size
5 μm
pore size
180 Å
operating pH range
2-8
application(s)
food and beverages
separation technique
reversed phase
Quality Level
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Application
Discovery® C8 HPLC 色谱柱可用于通过固相微萃取（SPME）和之后的高效液相色谱-串联质谱（HPLC-MS / MS）联用法测定包括尿液、培养物和组织在内的生物基质中的双酚A、染料木黄酮、双酚A β-D-葡萄糖醛酸 (BPA gluc) 和染料木黄酮4′-β-D-葡萄糖醛酸 (genistein gluc)。
Features and Benefits
- 优良的重现性。
- 分析强疏水性化合物时比 C18 柱快
- 稳定性好、低流失，适用于 LC-MS 分析
- 分析碱性和酸性化合物均可获得良好峰形
- 可兼容低有机溶剂/高含水量的流动相
Legal Information
Discovery is a registered trademark of Merck KGaA, Darmstadt, Germany
Measurement of bisphenol A, bisphenol A β-d-glucuronide, genistein, and genistein 4′- β-d-glucuronide via SPE and HPLC-MS/MS.
Coughlin LJ, et al.
Analytical and Bioanalytical Chemistry, 401, 995-1002 (2011)
Scott C Bell et al.
Pharmacology & therapeutics, 145, 19-34 (2014-06-17)
With the discovery of the CFTR gene in 1989, the search for therapies to improve the basic defects of cystic fibrosis (CF) commenced. Pharmacological manipulation provides the opportunity to enhance CF transmembrane conductance regulator (CFTR) protein synthesis and/or function. CFTR
Bo-Rui Kang et al.
Bioorganic & medicinal chemistry letters, 25(24), 5808-5812 (2015-11-08)
2-Benzylisoquinolin-1(2H)-ones has been proposed as vasodilative agents on the basis of scaffold hopping. In the present study, a series of 2-benzylisoquinolin-1(2H)-ones were synthesized. Their vasodilative effects were evaluated by wire myograph on isolated rat mesenteric arterial ring induced contraction with
G L Bundy et al.
The Journal of biological chemistry, 261(2), 747-751 (1986-01-15)
The gorgonian coral Pseudoplexaura porosa contains a lipoxygenase capable of converting exogenous arachidonic acid into (8R)-8-hydroperoxy-5,9,11,14-eicosatetraenoic acid. The (8R)- (or 8-L-) configuration in this product, opposite to that observed in previously reported 8-lipoxygenase products, was determined unambiguously by comparison of
Hugo M Botelho et al.
Scientific reports, 5, 9038-9038 (2015-03-13)
Plasma membrane proteins are essential molecules in the cell which mediate interactions with the exterior milieu, thus representing key drug targets for present pharma. Not surprisingly, protein traffic disorders include a large range of diseases sharing the common mechanism of
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