推荐产品
产品名称
SUPELCOSIL ™ LC-ABZ HPLC 色谱柱, 5 μm particle size, L × I.D. 15 cm × 4.6 mm
物料
stainless steel column
质量水平
Agency
suitable for USP L60
产品线
SUPELCOSIL™
特点
endcapped
制造商/商品名称
SUPELCOSIL™
包装
1 ea of
标记范围
12.0% carbon loading
参数
≤70 °C temp. limit
400 bar pressure (5801 psi)
技术
HPLC: suitable
长度 × 内径
15 cm × 4.6 mm
表面积
170 m2/g
表面覆盖度
surface coverage 3.4 μmol/m2
基质
silica gel, spherical particle platform
fully porous particle
基质活性基团
amide, alkyl phase
粒径
5 μm
孔径
120 Å
pH值范围
2-7.5
应用
food and beverages
分离技术
reversed phase
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一般描述
SUPELCOSIL LC-ABZ 相具有独特的去活技术，该可为碱性化合物以及酸性、中性和非极性化合物提供出色的反相性能。不需要采取使用同类胺在高离子强度下运行，以及调节流动相的极端 pH 值来抑制硅烷醇活性，就可以在 LC-ABZ 相上获得良好的峰形。
应用
- 奈韦拉平原料药中相关有机杂质的高效液相色谱检测方法的验证。：本文验证了使用SUPELCOSIL™ LC-ABZ HPLC色谱柱评估HIV药物纯度和杂质的方法，展示了该色谱柱的高特异性和重现性（Li et al., 2000）。
- S-腺苷-L-蛋氨酸及其相关代谢物在Hypersil ODS和Supelcosil LC-ABZ固定相上的反相HPLC保留行为的比较研究。：这项比较研究深入探讨了生物活性化合物在SUPELCOSIL™ LC-ABZ上的保留行为，肯定了其在复杂生化分离中的通用性和强大性能（Valkó et al., 1993）。
特点和优势
• 用于酸性、碱性、两性离子
• 相对于标准反相具有更大的极性保留性
• 独特的选择性
• 硅烷醇去活
• 对于非极性分析物，峰形、柱效和保留性相当于 C8 相
• 相对于标准反相具有更大的极性保留性
• 独特的选择性
• 硅烷醇去活
• 对于非极性分析物，峰形、柱效和保留性相当于 C8 相
法律信息
SUPELCOSIL is a trademark of Sigma-Aldrich Co. LLC
储存分类代码
11 - Combustible Solids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
D Korakas et al.
Journal of pharmaceutical and biomedical analysis, 12(9), 1141-1145 (1994-09-01)
A series of biologically active peptides and their conjugates with lipidic amino acids were investigated by systematic change of the mobile phase composition using traditional octadecylsilica stationary phase and the newly developed Supelcosil LC-ABZ column. The mobile phases contained various
Murali Pendela et al.
Journal of separation science, 32(20), 3418-3424 (2009-09-19)
Streptomycin (SM) is composed of streptidine, streptose and N-methyl glucosamine sugar moieties. For the determination of SM and its related substances, an ion-pair LC-UV detection method using a Supelcosil LC-ABZ column was developed previously. While analyzing commercial samples, several unknown
Q C Li et al.
Journal of chromatographic science, 38(6), 246-254 (2000-07-13)
Nevirapine (Viramune), a dipyridiodiazepinone, is a potent and highly specific nonnucleoside inhibitor of HIV-1 reverse transcriptase. This paper describes the validation of a specific, sensitive, and stability-indicating high-performance liquid chromatography method for the assay and determination of related organic impurities
J A López et al.
Journal of chromatography. A, 870(1-2), 105-114 (2000-03-18)
A high-performance liquid chromatographic method with electrochemical detection has been developed for the determination of six 1,4-dihydropyridines: nifedipine, nimodipine, nisoldipine, nicardipine, felodipine and lacidipine. The chromatographic separation was performed using a Supelcosil LC-ABZ+Plus C18 column. A mobile phase of methanol-water
Ana B Baranda et al.
Journal of chromatography. A, 1031(1-2), 275-280 (2004-04-03)
A high-performance liquid chromatographic method with electrochemical detection was developed for the simultaneous determination of five 1,4-dihydropyridines: amlodipine, nitrendipine, felodipine, lacidipine and lercanidipine. These drugs are widely used in the treatment of hypertension, angina pectoris and the therapy of cerebrovascular
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