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product name
SUPELCOSIL™ LC-CN HPLC 柱, 5 μm particle size, L × I.D. 15 cm × 4.6 mm
物料
stainless steel column
质量水平
Agency
suitable for USP L10
产品线
SUPELCOSIL™
特点
endcapped
包装
1 ea of
标记范围
4% Carbon loading
参数
≤70 °C temp. range
技术
HPLC: suitable
长度 × 内径
15 cm × 4.6 mm
表面积
170 m2/g
表面覆盖度
surface coverage 3.5 μmol/m2
基质
silica gel, spherical particle platform
fully porous particle
基质活性基团
cyano phase
粒径
5 μm
孔径
120 Å
pH值范围
2-7.5
分离技术
hydrophilic interaction (HILIC)
normal phase
reversed phase
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相关类别
一般描述
LC-CN 相通常作为硅胶相的替代者，因为它具有键合相的优点（例如快速平衡，以及对于流动相中水分含量的微小变化更不敏感）。然而 LC-CN 柱通常是在反相的流动相条件下运行。
应用
- Validated Simple HPLC-UV Method for Mycophenolic Acid (MPA) Monitoring in Human Plasma. Internal Standardization: : This study presents a validated HPLC-UV method for monitoring mycophenolic acid in human plasma. The research highlights the necessity and efficiency of internal standardization in achieving accurate measurements. (Kunicki PK et al., 2021).
- An Improved HPLC Method for Therapeutic Drug Monitoring of Daunorubicin, Idarubicin, Doxorubicin, Epirubicin, and Their 13-dihydro Metabolites in Human Plasma.: This paper describes an enhanced HPLC method for monitoring therapeutic levels of several chemotherapeutic agents and their metabolites in human plasma, improving the accuracy and reliability of drug monitoring. (Fogli S et al., 1999).
- Analysis of Diltiazem and Desacetyldiltiazem in Serum by High-Performance Liquid Chromatography.: This research focuses on an HPLC method for analyzing diltiazem and its primary metabolite in serum, providing a robust tool for clinical pharmacokinetic studies. (Paczkowski D et al., 1995).
- High-Performance Liquid Chromatographic Method for the Determination of Eclanamine and Its N-Desmethyl and N,N-Didesmethyl Metabolites in Urine.: The study details a high-performance liquid chromatographic method for determining eclanamine and its metabolites in urine, crucial for pharmacokinetic and toxicological analysis. (Lakings DB et al., 1988).
法律信息
SUPELCOSIL is a trademark of Sigma-Aldrich Co. LLC
法规信息
新产品
S Fogli et al.
Therapeutic drug monitoring, 21(3), 367-375 (1999-06-12)
A single high-performance liquid chromatography (HPLC) method, suitable for the analysis of daunorubicin, idarubicin, doxorubicin, epirubicin, and their 13-dihydro metabolites is validated in the present study. Preparation of plasma samples was performed by a first extraction of analytes with a
H Kataoka et al.
Journal of chromatography. B, Biomedical sciences and applications, 731(2), 353-359 (1999-10-08)
The technique of automated in-tube solid-phase microextraction (SPME) coupled with liquid chromatography-electrospray ionization mass spectrometry (LC-ESI-MS) was evaluated for the determination of ranitidine. In-tube SPME is an extraction technique for organic compounds in aqueous samples, in which analytes are extracted
H Kataoka et al.
Journal of analytical toxicology, 24(4), 257-265 (2000-06-29)
A simple and rapid method for the determination of amphetamine, methamphetamine, and their 3,4-methylenedioxy derivatives in urine samples was developed using automated in-tube solid-phase microextraction (SPME) coupled with liquid chromatography-electrospray ionization mass spectrometry (LC-ESI-MS). In-tube SPME is an extraction technique
D Paczkowski et al.
Polish journal of pharmacology, 47(5), 429-434 (1995-09-01)
This paper describes a simple high-performance liquid chromatographic (HPLC) method for the determination of diltiazem and desacetyldiltiazem in human serum. After basic methyl-tert-butyl ether extraction and back-extraction with hydrochloric acid, the drug and its metabolite was injected into a Supelcosil
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