产品名称
Discovery® HS C18 高效液相色谱柱, 3 μm particle size, L × I.D. 15 cm × 4.6 mm
material
stainless steel column
agency
suitable for USP L1
product line
Discovery®
feature
endcapped
manufacturer/tradename
Discovery®
packaging
1 ea of
extent of labeling
20% Carbon loading
parameter
≤70 °C temp. range
400 bar pressure (5801 psi)
technique(s)
HPLC: suitable
LC/MS: suitable
L × I.D.
15 cm × 4.6 mm
surface area
300 m2/g
surface coverage
3.2 μmol/m2
impurities
<10 ppm metals
matrix
silica gel, high purity, spherical particle platform
fully porous particle
matrix active group
C18 (octadecyl) phase
particle size
3 μm
pore size
120 Å
operating pH range
2-8
application(s)
food and beverages
separation technique
reversed phase
Quality Level
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Application
- 一种稳定性指示RP-HPLC方法，用于渗透性研究中以纳米制剂应用的COVID-19药物莫努匹韦的测定。：本研究开发了一种稳健的RP-HPLC方法，定量分析以纳米制剂应用的COVID-19治疗药物莫努匹韦。研究重点介绍了该方法在渗透性研究中的稳定性和有效性，证明了其在药物分析中的潜力（Reçber et al., 2022）。
- HPLC-UV法分析血浆中的特立齐酮及其在耐药结核病患者药代动力学研究中的应用。：研究开发并验证了一种分析血浆中特立齐酮的HPLC-UV方法，这对于耐药结核病患者的药代动力学研究至关重要。该方法的可靠性足够用于临床和药理学研究中（Mulubwa and Mugabo, 2018）。
- 从药代动力学、生物医学和药物监测治疗研究的角度优化定量检测血浆和尿液样品中阿霉素的LC方法。：本研究的重点是优化液相色谱法，对血浆和尿液中的阿霉素进行定量。这对于药代动力学、生物医学和药物监测研究至关重要，可确保治疗监测的准确性和精密度（Maliszewska et al., 2018）。
- 通用HPLC-UV法测定转运研究、大鼠胎盘灌注和胎盘裂解物中的依非韦伦。：本研究开发了一种通用的HPLC-UV方法，可测定转运研究、大鼠胎盘灌注和裂解物等各种生物基质中的依非韦伦。这对药代动力学和药物分布研究具有重要意义（Zelena et al., 2017）。
Features and Benefits
- 稳定性好、低流失，适用于 LC-MS 分析
- 提供有适用于分析型到制备型的各种规格
- 稳定性好，以确保柱与柱和批与批之间之间优良的重现性
- 更强的疏水性能够更好地分离难分析化合物
Legal Information
Discovery is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
13 - Non Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Abad Khan et al.
Talanta, 84(3), 789-801 (2011-04-13)
A new, simple, economical and validated high-performance liquid chromatography linked with electrochemical detector (HPLC-ECD) method has been developed and optimized for different experimental parameters to analyze the most common monothiols and disulfide (cystine, cysteine, homocysteine, methionine, reduced (GSH) and oxidized
Awantika Singh et al.
Rapid communications in mass spectrometry : RCM, 29(6), 485-496 (2015-07-15)
Adhatoda beddomei and Adhatoda vasica are popular Ayurvedic medicinal plants in India, belonging to the family Acanthaceae. Tricyclic quinazoline alkaloids are found to be the most abundant in these plants which are responsible for broad-spectrum medicinal properties. This study aims
Swati Jaiswal et al.
Journal of chromatographic science, 55(6), 617-624 (2017-03-24)
Tuberculosis (TB) with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome represents the most common infectious diseases worldwide. Anti-TB drugs are used concurrently with antiretroviral drug for treatment of TB-HIV co-morbidities. Due to lower risk of interaction with protease inhibitors, rifabutin is
Jolanta Flieger et al.
Journal of separation science, 34(7), 733-739 (2011-03-02)
Highly hydrophilic compounds belonging to biogenic amines were analysed in the reversed-phase system, modified with the addition of ionic liquids: 1-ethyl-3-methyl-imidazolium hexafluorophosphate (EMIM PF(6)) and chaotropic salt NaPF(6) on Discovery HS C18 column at acidic conditions. The effect of the
Abad Khan et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 878(28), 2782-2788 (2010-09-11)
A rapid, inexpensive, sensitive and specific HPLC-ECD method for the determination of lipoic acid in human plasma was developed and validated over the linearity range of 0.001-10μg/ml using naproxen sodium as an internal standard (IS). Extraction of lipoic acid and
相关内容
HPLC DiscoveryBIO HS C18 products. Available in 3µm, 5µm and 10µm particle sizes.
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