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Merck
CN
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文件

安全信息

48599

Supelco

2,3,7,8-四氯二苯并对二噁英 溶液

analytical standard

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别名:
2,3,7,8-TCDD
CAS号:
1746-01-6
EC 号:
203-625-9
UNSPSC代码:
12000000

等级

analytical standard

CofA

current certificate can be downloaded

包装

ampule of 1 mL

储存温度

2-8°C

InChI

1S/C12H4Cl4O2/c13-5-1-9-10(2-6(5)14)18-12-4-8(16)7(15)3-11(12)17-9/h1-4H

InChI key

HGUFODBRKLSHSI-UHFFFAOYSA-N

一般描述

2,3,7,8-四氯二苯并 p -二恶英是一种高度分散的环境污染物 ，由工业活动释放，可作为所有脊椎动物的生殖毒物和内分泌干扰物。
2,3,7,8-四氯二苯并-对-二恶英是二恶英和类二恶英类化学物质的强效同源物，能对用于研究的实验动物产生不利影响。

应用

以 2,3,7,8-四氯二苯并 p 二恶英溶液已作为标准品，用于采用高效气相色谱-质谱法 (HPGC-HPMS)研究 2,3,7,8-四氯二苯并 p 二恶英对鱼类后代的影响。
有关合适的仪器技术的更多信息，请参阅产品′的检验报告。想要获得更多支持，请联系技术服务部。

警示用语：

Danger

危险分类

Aquatic Chronic 1 - Asp. Tox. 1 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 2 - STOT SE 3

靶器官

Central nervous system

WGK

WGK 3

闪点(°F)

closed cup

闪点(°C)

closed cup

法规信息

新产品

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. Is Product No. 48599, 2,3,7,8-Tetrachlorodibenzo-p-dioxin solution, appropriate for use in tissue culture studies?

    The 2,3,7,8-Tetrachlorodibenzo-p-dioxin solution (10 μg/mL in toluene), is sold as 1mL in a flame sealed ampule.  It is made to be used as a chemical standard with US EPA drinking and wastewater analytical methods.  We have no knowledge of its use in tissue culture.

  4. Can I get pure 2,3,7,8-Tetrachlorodibenzo-p-dioxin from Sigma-Aldrich?

    No; Sigma-Aldrich has no source for pure 2,3,7,8-Tetrachlorodibenzo-p-dioxin.  It is only available as Supelco 48599: 2,3,7,8-TCDD, 10 μg/mL in toluene, ampule of 1mL.

  5. What is the molecular weight of 2,3,7,8-Tetrachlorodibenzo-p-dioxin, Product 48599?

    The molecular weight of 2,3,7,8-TCDD is 321.97 Da.  

  6. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  7. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Filomena Fiorito et al.
Toxicology, 290(2-3), 258-270 (2011-10-22)
The administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to a variety of cultured cells may alter their ability to proliferate and die. In a previous study we demonstrated that TCDD induced proliferation in Madin-Darby Bovine Kidney (MDBK) cells where no signs of apoptosis
E C Rada et al.
Chemosphere, 110, 53-61 (2014-06-02)
Atmospheric depositions of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and polychlorinated biphenyls (PCBs) were monitored at three sites in the vicinity of a steel making plant, located in an Italian alpine valley. A high variability in the deposition of PCDD/Fs was
K A Solak et al.
Toxicology, 311(3), 124-134 (2013-07-23)
The aryl hydrocarbon receptor (AhR) is involved in a wide variety of biological and toxicological responses, including neuroendocrine signaling. Due to the complexity of neuroendocrine pathways in e.g. the hypothalamus and pituitary, there are limited in vitro models available despite
Maria Herlin et al.
Toxicology and applied pharmacology, 273(1), 219-226 (2013-09-17)
Bone is a target for high affinity aryl hydrocarbon receptor (AHR) ligands, such as dioxins. Although bone morphology, mineral density and strength are sensitive endpoints of dioxin toxicity, less is known about effects on bone microarchitecture and material properties. This
Hongtao Shang et al.
Environment international, 54, 50-58 (2013-02-19)
A total of 60 paired samples of earthworm, corresponding soil and wormcast were collected to investigate the bioaccumulation tendency of polychlorinated dibenzo-p-dioxins/dibenzofurans (PCDD/Fs), polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) in earthworms from a typical E-waste dismantling area in
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