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安全信息

40334

Supelco

N-亚硝基二乙胺(NDEA) 溶液

certified reference material, 5000 μg/mL in methanol

别名:

二乙基亚硝胺

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About This Item

CAS号:
55-18-5
MDL编号:
MFCD00013890
UNSPSC代码:
41116105

等级

certified reference material
TraceCERT®

质量水平

300

产品线

TraceCERT®

CofA

current certificate can be downloaded

包装

ampule of 1 mL

浓度

5000 μg/mL in methanol

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

cleaning products
cosmetics
environmental
food and beverages
personal care

包装形式

single component solution

储存温度

2-8°C

SMILES字符串

N(N=O)(CC)CC

InChI

1S/C4H10N2O/c1-3-6(4-2)5-7/h3-4H2,1-2H3

InChI key

WBNQDOYYEUMPFS-UHFFFAOYSA-N

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相关类别

一般描述

该认证标准物质（CRM）根据ISO 17034和ISO/IEC 17025生产和认证。本CRM的所有使用信息参见分析证书(COA)。

N-亚硝基二乙胺属于有毒亚硝胺类物质，具有致癌、致突变性和肝毒性。在食品加工、药物加工和水处理中以副产物形式产生，因此常见于水体、鱼类、肉类和药品等。

应用

CRM的用途如下：
  • 采用液相色谱-电喷雾电离-串联质谱法(LC-ESI-MS/MS)，同时分析化妆品样中的N-亚硝基二乙醇胺、N-亚硝基二乙胺、三乙醇胺、二乙醇胺。
  • 固相萃取8种沙坦(sartan)、雷尼替丁和二甲双胍原料药及成品药(fortified product)中的N-亚硝基二乙胺和N-亚硝基甲基乙基胺，通过气相色谱-串联质谱(GC-MS/MS)法进行定量分析。
  • 采用涡旋反相分散液液微萃取法(VA-RP-DLLME)和液相色谱-质谱法(LC-MS)，多残留分析2种身体乳和2种沐浴露样品中的7种限用亚硝胺。
  • 通过气相色谱-串联质谱(GC-MS/MS)技术，定量分析4种沙坦类药物—坎地沙坦酯(candesartan cilexetil)、奥美沙坦酯(olmesartan medoxomil)、厄贝沙坦(irbesartan)和缬沙坦(valsartan)中的亚硝胺。
  • 采用超声溶剂萃取-固相微萃取(SPME)和GC-MS技术，测定28种流行肉制品样中的8种挥发性亚硝胺。

其他说明

有关合适的仪器技术的更多信息，请参阅产品′的检验报告。想要获得更多支持，请联系技术服务部。

法律信息

TraceCERT is a registered trademark of Merck KGaA, Darmstadt, Germany

警示用语：

Danger

危险分类

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Carc. 1B - Flam. Liq. 2 - STOT SE 1

靶器官

Eyes,Central nervous system

储存分类代码

3 - Flammable liquids

WGK

WGK 3

法规信息

危险化学品

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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Kei Tamura et al.
The Journal of toxicological sciences, 41(6), 801-811 (2016-11-18)
To clarify the major pathway of liver tumor development induced by imazalil (IMA), an imidazole fungicide, male constitutive androstane receptor (CAR)-knockout (CARKO) and wild-type (WT) mice were treated with IMA at 500 ppm in the diet up to 27 weeks
Hao Hu et al.
International journal of medical sciences, 17(13), 1897-1908 (2020-08-14)
Retinal dehydrogenase 5 (RDH5) is an important enzyme in the visual cycle. Several studies have reported that the RDH family may play crucial roles in tumor prognosis. However, the role of RDH5 in tumor prognosis is still unclear. We examined
Xu Zheng et al.
Nutrients, 10(3) (2018-03-03)
Thyroid cancer (TC) is the most common endocrine malignancy without reliable preventive agent. Resveratrol possesses in vitro anti-TC activities; while its effect(s) on thyroid tumorigenesis remains unknown. This study aims to address this issue using DEN/MNU/DHPN-induced rat carcinogenesis model. 50
L Verna et al.
Pharmacology & therapeutics, 71(1-2), 57-81 (1996-01-01)
N-Nitrosodiethylamine (NDEA) is DNA reactive after bioactivation and produces tumors in every animal species tested. Bioactivation is effected by several P450 isozymes including CYP2E1, which is ethanol inducible. Tumor formation in rat liver was proportional to O4-ethyldeoxythymidine formation in DNA
Esther Bertran et al.
Hepatology (Baltimore, Md.), 58(6), 2032-2044 (2013-07-03)
Transforming growth factor-beta (TGF-β) is an important regulatory suppressor factor in hepatocytes. However, liver tumor cells develop mechanisms to overcome its suppressor effects and respond to this cytokine by inducing other processes, such as the epithelial-mesenchymal transition (EMT), which contributes
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