推荐产品
product name
Astec® CHIROBIOTIC® V2手性HPLC色谱柱, 5 μm particle size, L × I.D. 25 cm × 21.2 mm
物料
stainless steel column
质量水平
Agency
suitable for USP L88
描述
HPLC column
产品线
Astec®
包装
pkg of 1 ea
制造商/商品名称
Astec®
参数
0-45 °C temperature
241 bar pressure (3500 psi)
技术
HPLC: suitable
LC/MS: suitable
长度 × 内径
25 cm × 21.2 mm
基质
High-purity silica gel particle platform
fully porous particle
基质活性基团
vancomycin phase
粒径
5 μm
孔径
200 Å
operating pH range
3.5-7.0
分离技术
chiral
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相关类别
一般描述
中性分子、酰胺、酸、酯和胺对这些基于万古霉素的CSP显示出相当大的对映选择性。在CHIROBIOTIC® V的极性离子模式下，分离出各种各样的仲胺和叔胺分子。CHIROBIOTIC® V已经表现出蛋白质固定相的许多分离特性，但同时具有出色的稳定性和更高的样品容量。一些尚未报道在任何其他手性固定相上得到分离的手性分析物被分离出来。CHIROBIOTIC® V和V2的区别在于键合化学性质与载体颗粒的孔径不同，这赋予它们不同的选择性和制备能力。
CHIROBIOTIC FAQ
CHIROBIOTIC参考书目
Chiral产品文献
- 键合相：万古霉素
- 工作pH范围：3.5 - 7.0
- 粒径：5、10或16 μm
- 孔径：100Å（CHIROBIOTIC® V）或200Å（CHIROBIOTIC® V2）
CHIROBIOTIC FAQ
CHIROBIOTIC参考书目
Chiral产品文献
应用
- Development and validation of an UFLC-MS/MS method for enantioselectivity determination of d,l-threo-methylphenidate, d,l-threo-ethylphenidate and d,l-threo-ritalinic acid in rat plasma and its application to pharmacokinetic study.: This study utilizes the Astec® CHIROBIOTIC® V2 Chiral HPLC Column to develop and validate a UFLC-MS/MS method for the enantioselective determination of various methylphenidate and ritalinic acid enantiomers in rat plasma. The column′s application in pharmacokinetic studies underscores its effectiveness in biomedical research, particularly in analyzing chiral drug molecules (Zhang et al., 2016).
- New high-performance liquid chromatography method for the determination of (R)-warfarin and (S)-warfarin using chiral separation on a glycopeptide-based stationary phase.: This research employs the Astec® CHIROBIOTIC® V2 Chiral HPLC Column for the chiral separation and determination of warfarin enantiomers. The study highlights the column′s utility in pharmaceutical analysis and its effectiveness in the study of chiral drug enantiomers (Malakova et al., 2009).
法律信息
Astec is a registered trademark of Merck KGaA, Darmstadt, Germany
CHIROBIOTIC is a registered trademark of Sigma-Aldrich Co. LLC
法规信息
新产品
Chromatography Liquid Chiral Separations
Xiao, T.L., et al.
Encyclopedia of Separation Science, 1-15 (2000)
Chiral derivatives of Butenafine and Terbinafine: synthesis and antifungal activity
Fuglseth, Erik, et al.
Tetrahedron, 65 (47), 9807-9813 (2009)
Enantiospecific determination of dl-methylphenidate and dl-ethylphenidate in plasma by liquid chromatography?tandem mass spectrometry: Application to human ethanol interactions
Zhu, Hao-Jie, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 879 (11-12), 783-788 (2011)
Direct and indirect separations of five isomers of Brivanib Alaninate using chiral high-performance liquid chromatography
He, Brian Lingfeng, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 875 (1), 122-135 (2008)
Doris Frühauf et al.
Journal of chromatography. A, 1269, 242-254 (2012-10-30)
A sub-minute enantioselective normal phase high performance liquid chromatographic (HPLC) method for the analysis of a chiral precursor molecule employed frequently in folic acid syntheses was developed, optimized and successfully validated according to ICH-guidelines. It could be shown that ultra-high
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