product name
Astec® CHIROBIOTIC® V 手性 HPLC 色谱柱, 5 μm particle size, L × I.D. 15 cm × 2.1 mm
物料
stainless steel column
质量水平
Agency
suitable for USP L88
描述
HPLC Column
产品线
Astec®
包装
pkg of 1 ea
制造商/商品名称
Astec®
参数
0-45 °C temperature
241 bar pressure (3500 psi)
技术
HPLC: suitable
LC/MS: suitable
长度 × 内径
15 cm × 2.1 mm
基质
High-purity silica gel particle platform
fully porous particle
基质活性基团
vancomycin phase
粒径
5 μm
孔径
100 Å
operating pH range
3.5-7.0
分离技术
chiral
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相关类别
一般描述
Astec CHIROBIOTIC® CSP（手性固定相）通过多种分子相互作用与可电离的极性和中性分析物相互作用。该属性使其具有广泛的通用性，从而使其可用于各种流动相。另一个特点存在离子相互作用，使它们可用于反相和极性离子模式进行敏感的 LC-MS 操作。CHIROBIOTIC® V 是基于结合万古霉素，万古霉素包含 18 个手性中心，周围有 3 个空腔或口袋。这些空腔被 5 个芳香环包围。氢受体和供体位点非常靠近环结构。CHIROBIOTIC® V 与糖蛋白相的选择性相似，不同之处在于它具有较高的样品容量，并且在 0-100％ 的有机改性剂中稳定。
中性分子、酰胺、酸、酯和胺对这些基于万古霉素的CSP具有相当大的对映选择性。在极性离子模式下，在CHIROBIOTIC® V上可分离多种仲胺和叔胺。CHIROBIOTIC® V已被证明具有许多蛋白质固定相的分离特性，但又具有优异的稳定性和更高的样品容量。部分尚无采用其他手性固定相分离报道的手性分析物也已在其上得到分离。CHIROBIOTIC® V和V2的成键化学特性不同，载体颗粒的孔径不同，因而各自具有不同的灵敏度和制备能力。
- 键合相：万古霉素
- 工作pH范围: 3.5 - 7.0
- 粒径：5、10或16 μm
- 孔径：100 Å (CHIROBIOTIC® V)或200 Å (CHIROBIOTIC® V2)
应用
Chirobiotic V HPLC 色谱柱可用于分离人血浆中西酞普兰的对映异构体及其两种 N-去甲基化代谢物和内标物阿普洛尔。
法律信息
Astec is a registered trademark of Merck KGaA, Darmstadt, Germany
CHIROBIOTIC is a registered trademark of Sigma-Aldrich Co. LLC
M Kosel et al.
Journal of chromatography. B, Biomedical sciences and applications, 719(1-2), 234-238 (1998-12-30)
A procedure using a chirobiotic V column is presented which allows separation of the enantiomers of citalopram and its two N-demethylated metabolites, and of the internal standard, alprenolol, in human plasma. Citalopram, demethylcitalopram and didemethylcitalopram, as well as the internal
Hisham Hashem et al.
Journal of chromatography. A, 1218(38), 6727-6731 (2011-08-23)
In this study, a method for enantioseparation of terbutaline and salbutamol was established using Chirobiotic V column as a stationary phase. Polar ionic mode applying mobile phase containing ammonium nitrate in 100% ethanol, pH 5.1 was found to give the
Ana R Ribeiro et al.
Chemosphere, 95, 589-596 (2013-11-05)
Microbial degradation is the most important process to remove organic pollutants in Waste Water Treatment Plants. Regarding chiral compounds this process is normally enantioselective and needs the suitable analytical methodology to follow the removal of both enantiomers in an accurate
Enantiomeric separation of mirtazapine and its metabolite in rat plasma by reverse polar ionic liquid chromatography using fluorescence and polarimetric detectors connected in series
Rao, R. Nageswara, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 879 (21), 1911-1916 (2011)
Chiral stability-indicating HPLC method for analysis of arotinolol in pharmaceutical formulation and human plasma
Sultan, Maha A., et al.
Arabian Journal of Chemistry, 3 (3), 147-153 (2010)
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