推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
IgG fraction of antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
antigen 82-84 kDa
种属反应性
mouse, human, rat
技术
indirect immunofluorescence: 1:100 using Rat1 cells
western blot (chemiluminescent): 1:1,000 using whole extract of human HeLa cells
western blot (chemiluminescent): 1:2,000 using whole extract of mouse NIH3T3 cells
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... ZYX(7791)
mouse ... Zyx(22793)
rat ... Zyx(114636)
一般描述
Zyxin (ZYX ), a zinc-binding phosphoprotein of ∼61kDa is located at focal adhesions and along the actin cytoskeleton. It has three LIM domains. This structural protein is located on human chromosome 7q34.
免疫原
synthetic peptide corresponding to amino acid residues 134-150 of human zyxin with N-terminal added cysteine conjugated to KLH. The corresponding sequence differs by one amino acid in mouse.
应用
Anti-Zyxin antibody has been used in fluorescence microscopy.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 papers)
Western Blotting (1 papers)
生化/生理作用
Zyxin (ZYX ) participates in the modulation of actin assembly at focal adhesions and stress fibers. It also regulates cell adhesion and cell cycle. Overexpression of ZYX is associated with melanoma. Suppression of ZYX prevents cell growth.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
Functional analysis of Zyxin in cell migration and invasive potential of oral squamous cell carcinoma cells Corrigendum in/10.3892/ijo. 2016.3702
Yamamura MN, et al.
International Journal of Oncology, 42(3), 873-880 (2013)
Loss of the mechanotransducer zyxin promotes a synthetic phenotype of vascular smooth muscle cells
Ghosh SK, et al.
Journal of the American Heart Association, 4(6), e001712-e001712 (2015)
Novel identification of zyxin upregulations in the motile phenotype of hepatocellular carcinoma
Sy SMH, et al.
Modern Pathology, 19(8), 1108-1108 (2006)
A cell culture model for investigation of Hirano bodies
Davis RC, et al.
Acta Neuropathologica, 115(2), 205-205 (2008)
Aniqua Rahman et al.
Molecular biology of the cell (2016-03-11)
During metastasis, cells can use proteolytic activity to form tube-like "microtracks" within the extracellular matrix (ECM). Using these microtracks, cells can migrate unimpeded through the stroma. To investigate the molecular mechanisms of microtrack migration, we developed an in vitro 3D
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