Z2626
扎格雷酸 A 三钠盐
from microbial, ≥95% (HPLC), lyophilized powder, squalene synthase inhibitor
别名:
L-694,599, 鲨烯合成抑制剂
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关于此项目
经验公式（希尔记法）:
C35H43O14Na3
化学文摘社编号:
分子量:
756.68
UNSPSC Code:
12352106
NACRES:
NA.77
MDL number:
产品名称
扎格雷酸 A 三钠盐, ≥95% (HPLC), microbial
biological source
microbial
assay
≥95% (HPLC)
form
lyophilized powder
solubility
DMSO: 9.80-10.20 mg/mL, clear, colorless to faintly yellow
shipped in
wet ice
storage temp.
−20°C
Quality Level
Application
萨拉哥（Zaragozic）酸 A 三钠盐可用作：
- 人类胚胎肾细胞的无血清培养基成分，在伤口刮擦测定中检测其对伤口愈合的作用
- 抑制剂，在基质细胞中抑制法尼基二磷酸法尼基转移酶1（FDFT1）或角鲨烯合成酶
- T细胞中的胆固醇合成抑制剂
Biochem/physiol Actions
哺乳动物，真菌和酿酒酵母角鲨烯合成酶的体内和体外有效抑制剂。角鲨烯合成酶是固醇合成中的第一个关键酶，催化焦磷酸法尼基还原缩合形成角鲨烯。作为角鲨烯合成酶抑制剂，扎格雷酸在灵长类动物中产生较低的血浆胆固醇水平。用扎格雷酸 A 处理大鼠导致肝脏低密度脂蛋白 (LDL) 受体 mRNA 水平升高。
Legal Information
根据 Merck & Co.,Inc.,Kenilworth,NJ 限制性授权许可生产和销售。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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