Z0167
玉米赤霉酮
≥98% (TLC), mycotoxin, powder
别名:
2,4-二羟基-6-（10-羟基-6-氧代十一烷基）苯甲酸 μ-内酯
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关于此项目
经验公式（希尔记法）:
C18H24O5
化学文摘社编号:
分子量:
320.38
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
玉米赤霉酮,
SMILES string
C[C@H]1CCCC(=O)CCCCCc2cc(O)cc(O)c2C(=O)O1
InChI
1S/C18H24O5/c1-12-6-5-9-14(19)8-4-2-3-7-13-10-15(20)11-16(21)17(13)18(22)23-12/h10-12,20-21H,2-9H2,1H3/t12-/m0/s1
InChI key
APJDQUGPCJRQRJ-LBPRGKRZSA-N
sterility
non-sterile
assay
≥98% (TLC)
form
powder
solubility
methanol: 9.80-10.20 mg/mL, clear, colorless
shipped in
ambient
storage temp.
−20°C
Quality Level
Gene Information
rat ... Ar(24208)
相关类别
General description
玉米赤霉酮(Zearalanone, ZEA) ，又称F-2毒素，是由各种镰刀菌产生的非甾体雌性真菌毒素。禾谷镰刀菌Fusarium graminearum被认为是玉米赤霉酮的主要生产菌种。它常见于发霉的干草、高水分含量的玉米、收割前感染的玉米。
Application
玉米赤霉酮已用于：
- 作为真菌毒素研究其对青春期前母犬中卵巢组织学的影响
- 作为真菌毒素研究其对母犬中免疫学、血液学和生化选定指数的影响
- 作为标准品建立校准曲线，用于研究其对青春期前雌性比格犬外周血中黄体酮与17β-雌二醇浓度和体重的影响
- 作为标准品建立校准曲线，用于研究其在生殖道瘤样病变女性中的毒性水平
Biochem/physiol Actions
玉米赤霉酮被认为会导致猪的外阴阴道炎和雌激素反应。
signalword
Warning
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
高风险级别生物产品--毒素类产品
此项目有
Influence of zearalenone micotoxicosis on selected immunological, haematological and biochemical indexes of blood plasma in bitches
Polak M, et al.
Polish Journal of Veterinary Sciences, 7(3), 175-180 (2004)
The effect of low doses of zearalenone and its metabolites on progesterone and 17b-estradiol concentrations in peripheral blood and body weights of pre-pubertal female Beagle dogs
Gajecka M, et al.
Toxicon, 76, 260-269 (2013)
Preliminary results of monitoring research on zearalenone presence in blood of women with neoplastic lesions in reproductive system
Gajecki M, et al.
Polish Journal of Veterinary Sciences, 7(2), 153-156 (2004)
Mathias Devreese et al.
Journal of agricultural and food chemistry, 63(20), 5092-5098 (2015-05-08)
After oral (PO) and intravenous (IV) administration of zearalenone (ZEN) to broiler chickens, laying hens, and turkey poults, the mycotoxin was rapidly absorbed (Tmax = 0.32-0.97 h) in all three species; however, the absolute oral bioavailability was low (F% =
Toxigenic fungi and mycotoxins in the barley-to-beer chain
Brewing Microbiology, 107-139 (2015)
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