一般描述
Research area: Cell CycleXanthineoxidase (XO) is a homodimer. It is made up of two sub-units each made up of onemolybdenum and two iron-sulphur (2Fe-2S) centers.
Formerly E.C.1.1.3.22
应用
Xanthine Oxidase from bovine milk has been used in superoxide dismutaseactivity assay.Xanthine oxidase may be suitable for producing amperometric biosensors and designing-flavonoid-type inhibitors against XO for treating inflammatory diseases, gout, and hyperuricemia. It may also be used in the synthesis of superoxide because of aldehyde oxidation.
生化/生理作用
木糖氧化酶是一种含钼酶，存在于细胞质中，能够被黄酮类化合物有效抑制。它在一些药物和嘌呤嘧啶代谢中有重要作用。它被认为是活性氧簇的生物来源。
虽然发现黄嘌呤氧化酶广泛分布于多种组织中，但它在内皮细胞和上皮细胞中高度表达。其在感染组织中的表达也增加，由于其能够产生活性氧，因此显示具有抗微生物作用。
单位定义
在 pH 值为 7.5、25°C 条件下，1 个单位的黄嘌呤每分钟转化为尿酸 1.0 μmol/min。次黄嘌呤作为底物时，可获得约 50% 的活性。
外形
含 1 mM 水杨酸钠的 2.3 M (NH4)2SO4 混悬液
分析说明
双缩脲法测定蛋白质
警示用语：
Danger
危险声明
预防措施声明
危险分类
Resp. Sens. 1
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
动植物源性产品
Szymon Byczkiewicz et al.
Nutrients, 16(11) (2024-06-19)
In the present study, the effect of the addition of quince and collagen type I and III to dessert chocolate on its functional properties was determined. The study evaluated the antioxidant potential of the tested formulations using the FRAP method
Evolution of the anticholinesterase, antioxidant, and anti-inflammatory activity of Epilobium angustifolium L. infusion during in vitro digestion
Szwajgier D, et al.
Journal of functional foods, 85, 104645-104645 (2021)
Role of xanthine oxidoreductase as an antimicrobial agent.
Hannah M Martin et al.
Infection and immunity, 72(9), 4933-4939 (2004-08-24)
M B Betancor et al.
Fish physiology and biochemistry, 41(3), 705-720 (2015-03-10)
In vertebrates, selenium (Se) is an essential micronutrient for vertebrates that is involved in antioxidant protection and thyroid hormone regulation among other roles and functions through its incorporation into proteins, the selenoproteins. Long-chain polyunsaturated fatty acids, such as docosahexaenoic acid
Xanthine oxidase: isolation, assays of activity, and inhibition
Kostic D, et al.
Journal of Chemistry, 2015(1), 294858-294858 (2015)
商品
以硫酸铵悬浮液形式提供的酶的使用指南
Instructions for working with enzymes supplied as ammonium sulfate suspensions
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